PF-05105679 is a drug which acts as a potent and selective blocker of the
TRPM8ion channel, which is the main receptor responsible for the sensation of
cold. It was developed as a potential
analgesic, and blocks the sensation of cold in both animals and human trials. It also lowers
core body temperature in small mammals, but does not produce this effect in humans in the normal dosage range.[1][2][3]
^Gosset JR, Beaumont K, Matsuura T, Winchester W, Attkins N, Glatt S, et al. (November 2017). "A cross-species translational pharmacokinetic-pharmacodynamic evaluation of core body temperature reduction by the TRPM8 blocker PF-05105679". European Journal of Pharmaceutical Sciences. 109S: S161–S167.
doi:
10.1016/j.ejps.2017.06.009.
PMID28603038.
S2CID28787846.
PF-05105679 is a drug which acts as a potent and selective blocker of the
TRPM8ion channel, which is the main receptor responsible for the sensation of
cold. It was developed as a potential
analgesic, and blocks the sensation of cold in both animals and human trials. It also lowers
core body temperature in small mammals, but does not produce this effect in humans in the normal dosage range.[1][2][3]
^Gosset JR, Beaumont K, Matsuura T, Winchester W, Attkins N, Glatt S, et al. (November 2017). "A cross-species translational pharmacokinetic-pharmacodynamic evaluation of core body temperature reduction by the TRPM8 blocker PF-05105679". European Journal of Pharmaceutical Sciences. 109S: S161–S167.
doi:
10.1016/j.ejps.2017.06.009.
PMID28603038.
S2CID28787846.