SN-2 is a chemical compound which acts as an "agonist" (i.e. channel opener) for the
TRPML3 calcium channel, with high selectivity for TRPML3 and no significant activity at the related
TRPML1 and
TRPML2 channels.[1] It has demonstrated
antiviral activity in an in vitro model.[2]
^Xia Z, Wang L, Li S, Tang W, Sun F, Wu Y, et al. (October 2020). "ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity". Antiviral Research. 182: 104922.
doi:
10.1016/j.antiviral.2020.104922.
PMID32858116.
S2CID221365410.
SN-2 is a chemical compound which acts as an "agonist" (i.e. channel opener) for the
TRPML3 calcium channel, with high selectivity for TRPML3 and no significant activity at the related
TRPML1 and
TRPML2 channels.[1] It has demonstrated
antiviral activity in an in vitro model.[2]
^Xia Z, Wang L, Li S, Tang W, Sun F, Wu Y, et al. (October 2020). "ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity". Antiviral Research. 182: 104922.
doi:
10.1016/j.antiviral.2020.104922.
PMID32858116.
S2CID221365410.