Kv channel-interacting protein 2 also known as KChIP2 is a
protein that in humans is encoded by the KCNIP2gene.[5][6]
Function
This gene encodes a member of the family of voltage-gated potassium (
Kv) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the
recoverin branch of the
EF-hand superfamily.[7] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the
N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.[6]
Ohya S, Morohashi Y, Muraki K, Tomita T, Watanabe M, Iwatsubo T, Imaizumi Y (Mar 2001). "Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2". Biochemical and Biophysical Research Communications. 282 (1): 96–102.
doi:
10.1006/bbrc.2001.4558.
PMID11263977.
Lin YL, Lin SR, Wu TT, Chang LS (Jul 2004). "Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins". Biochemical and Biophysical Research Communications. 319 (3): 720–4.
doi:
10.1016/j.bbrc.2004.05.064.
PMID15184042.
Lin YL, Chen CY, Cheng CP, Chang LS (Aug 2004). "Protein-protein interactions of KChIP proteins and Kv4.2". Biochemical and Biophysical Research Communications. 321 (3): 606–10.
doi:
10.1016/j.bbrc.2004.07.006.
PMID15358149.
Kv channel-interacting protein 2 also known as KChIP2 is a
protein that in humans is encoded by the KCNIP2gene.[5][6]
Function
This gene encodes a member of the family of voltage-gated potassium (
Kv) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the
recoverin branch of the
EF-hand superfamily.[7] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the
N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.[6]
Ohya S, Morohashi Y, Muraki K, Tomita T, Watanabe M, Iwatsubo T, Imaizumi Y (Mar 2001). "Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2". Biochemical and Biophysical Research Communications. 282 (1): 96–102.
doi:
10.1006/bbrc.2001.4558.
PMID11263977.
Lin YL, Lin SR, Wu TT, Chang LS (Jul 2004). "Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins". Biochemical and Biophysical Research Communications. 319 (3): 720–4.
doi:
10.1016/j.bbrc.2004.05.064.
PMID15184042.
Lin YL, Chen CY, Cheng CP, Chang LS (Aug 2004). "Protein-protein interactions of KChIP proteins and Kv4.2". Biochemical and Biophysical Research Communications. 321 (3): 606–10.
doi:
10.1016/j.bbrc.2004.07.006.
PMID15358149.