From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Serine/threonine-protein kinase Nek8 , also known as never in mitosis A-related kinase 8 , is an
enzyme that in humans is encoded by the NEK8
gene .
[5]
[6]
Nek8 is a member of the
serine/threonine-specific protein kinase family related to NIMA (never in mitosis, gene A) of
Aspergillus nidulans . The encoded protein may play a role in
cell cycle progression from
G2 to
M phase .
[5]
Mutations in the NEK8 gene associated with
nephronophthisis .
[7]
[8]
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000160602 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000017405 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b
"Entrez Gene: NIMA (never in mitosis gene a)- related kinase 8" .
^ Otto EA, Trapp ML, Schultheiss UT, Helou J, Quarmby LM, Hildebrandt F (March 2008).
"NEK8 mutations affect ciliary and centrosomal localization and may cause nephronophthisis" . J. Am. Soc. Nephrol . 19 (3): 587–92.
doi :
10.1681/ASN.2007040490 .
PMC
2391043 .
PMID
18199800 .
^ Lancaster MA, Gleeson JG (June 2009).
"The primary cilium as a cellular signaling center: lessons from disease" . Curr. Opin. Genet. Dev . 19 (3): 220–9.
doi :
10.1016/j.gde.2009.04.008 .
PMC
2953615 .
PMID
19477114 .
^ Zalli, D.; Bayliss, R.; Fry, A. M. (21 November 2011).
"The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis" . Human Molecular Genetics . 21 (5): 1155–1171.
doi :
10.1093/hmg/ddr544 .
PMC
3277313 .
PMID
22106379 .
Bowers AJ, Boylan JF (2004). "Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors". Gene . 328 : 135–42.
doi :
10.1016/j.gene.2003.12.002 .
PMID
15019993 .
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science . 307 (5715): 1621–5.
Bibcode :
2005Sci...307.1621B .
doi :
10.1126/science.1105776 .
PMID
15761153 .
S2CID
39457788 .
Valkova N, Yunis R, Mak SK, et al. (2005).
"Nek8 mutation causes overexpression of galectin-1, sorcin, and vimentin and accumulation of the major urinary protein in renal cysts of jck mice" . Mol. Cell. Proteomics . 4 (7): 1009–18.
doi :
10.1074/mcp.M500091-MCP200 .
PMID
15872312 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Holland PM, Milne A, Garka K, et al. (2002).
"Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2" . J. Biol. Chem . 277 (18): 16229–40.
doi :
10.1074/jbc.M108662200 .
PMID
11864968 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2002).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Simms RJ, Eley L, Sayer JA (2009).
"Nephronophthisis" . Eur. J. Hum. Genet . 17 (4): 406–16.
doi :
10.1038/ejhg.2008.238 .
PMC
2986221 .
PMID
19066617 .
Wu C, Ma MH, Brown KR, et al. (2007). "Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening". Proteomics . 7 (11): 1775–85.
doi :
10.1002/pmic.200601006 .
PMID
17474147 .
S2CID
22474278 .
Activity Regulation Classification Kinetics Types