Mitogen-activated protein kinase kinase kinase 14 also known as NF-kappa-B-inducing kinase (NIK) is an
enzyme that in humans is encoded by the MAP3K14gene.[5][6]
Function
This gene encodes mitogen-activated protein kinase kinase kinase 14, NIK, which is a
serine/threonine protein-kinase. This kinase binds to
TRAF2 and stimulates
NF-κB activity. It is a critical kinase of the alternative NF-κB activation pathway. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-κB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (
TNF/
NGF) family and to the
interleukin-1 type-I receptor.[6]
^Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K (March 1999). "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway". Nature. 398 (6724): 252–6.
Bibcode:
1999Natur.398..252N.
doi:
10.1038/18465.
PMID10094049.
S2CID4421236.
Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K (1999). "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway". Nature. 398 (6724): 252–6.
Bibcode:
1999Natur.398..252N.
doi:
10.1038/18465.
PMID10094049.
S2CID4421236.
Delhase M, Hayakawa M, Chen Y, Karin M (1999). "Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation". Science. 284 (5412): 309–13.
doi:
10.1126/science.284.5412.309.
PMID10195894.
Mitogen-activated protein kinase kinase kinase 14 also known as NF-kappa-B-inducing kinase (NIK) is an
enzyme that in humans is encoded by the MAP3K14gene.[5][6]
Function
This gene encodes mitogen-activated protein kinase kinase kinase 14, NIK, which is a
serine/threonine protein-kinase. This kinase binds to
TRAF2 and stimulates
NF-κB activity. It is a critical kinase of the alternative NF-κB activation pathway. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-κB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (
TNF/
NGF) family and to the
interleukin-1 type-I receptor.[6]
^Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K (March 1999). "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway". Nature. 398 (6724): 252–6.
Bibcode:
1999Natur.398..252N.
doi:
10.1038/18465.
PMID10094049.
S2CID4421236.
Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K (1999). "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway". Nature. 398 (6724): 252–6.
Bibcode:
1999Natur.398..252N.
doi:
10.1038/18465.
PMID10094049.
S2CID4421236.
Delhase M, Hayakawa M, Chen Y, Karin M (1999). "Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation". Science. 284 (5412): 309–13.
doi:
10.1126/science.284.5412.309.
PMID10195894.