MNK2 has been identified as a therapeutic target for
diabetes. Specifically, blocking MNK2 interaction with eIF4G has been shown to boost protein synthesis and promote
beta cell regeneration.[9]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Slentz-Kesler K, Moore JT, Lombard M, Zhang J, Hollingsworth R, Weiner MP (October 2000). "Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta". Genomics. 69 (1): 63–71.
doi:
10.1006/geno.2000.6299.
PMID11013076.
Wang P, Wang X, Wang F, Cai T, Luo Y (June 2006). "Interaction between Mnk2 and CBC(VHL) ubiquitin ligase E3 complex". Science in China Series C: Life Sciences. 49 (3): 265–273.
doi:
10.1007/s11427-006-0265-5.
PMID16856496.
S2CID23339861.
MNK2 has been identified as a therapeutic target for
diabetes. Specifically, blocking MNK2 interaction with eIF4G has been shown to boost protein synthesis and promote
beta cell regeneration.[9]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Slentz-Kesler K, Moore JT, Lombard M, Zhang J, Hollingsworth R, Weiner MP (October 2000). "Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta". Genomics. 69 (1): 63–71.
doi:
10.1006/geno.2000.6299.
PMID11013076.
Wang P, Wang X, Wang F, Cai T, Luo Y (June 2006). "Interaction between Mnk2 and CBC(VHL) ubiquitin ligase E3 complex". Science in China Series C: Life Sciences. 49 (3): 265–273.
doi:
10.1007/s11427-006-0265-5.
PMID16856496.
S2CID23339861.