Serine/threonine-protein kinase 4 is an
enzyme that in humans is encoded by the STK4gene.[5][6][7]
Function
The protein encoded by this gene is a
cytoplasmic kinase that is structurally similar to the yeast Ste20p (sterile 20 protein) kinase, which acts upstream of the stress-induced
mitogen-activated protein kinase (MAPK) cascade. The encoded protein can
phosphorylatemyelin basic protein and undergoes
autophosphorylation. A
caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating
histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with
apoptosis, and it's possible that this protein induces the
chromatin condensation observed in this process.[8]
de Souza PM, Lindsay MA (2004). "Mammalian Sterile20-like kinase 1 and the regulation of apoptosis". Biochem. Soc. Trans. 32 (Pt3): 485–8.
doi:
10.1042/BST0320485.
PMID15157167.
Han S, Stuart LA, Degen SJ (1991). "Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor". Biochemistry. 30 (40): 9768–80.
doi:
10.1021/bi00104a029.
PMID1655021.
Schultz SJ, Nigg EA (1993). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30.
PMID8274451.
Creasy CL, Chernoff J (1995). "Cloning and characterization of a member of the MST subfamily of Ste20-like kinases". Gene. 167 (1–2): 303–6.
doi:
10.1016/0378-1119(95)00653-2.
PMID8566796.
Serine/threonine-protein kinase 4 is an
enzyme that in humans is encoded by the STK4gene.[5][6][7]
Function
The protein encoded by this gene is a
cytoplasmic kinase that is structurally similar to the yeast Ste20p (sterile 20 protein) kinase, which acts upstream of the stress-induced
mitogen-activated protein kinase (MAPK) cascade. The encoded protein can
phosphorylatemyelin basic protein and undergoes
autophosphorylation. A
caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating
histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with
apoptosis, and it's possible that this protein induces the
chromatin condensation observed in this process.[8]
de Souza PM, Lindsay MA (2004). "Mammalian Sterile20-like kinase 1 and the regulation of apoptosis". Biochem. Soc. Trans. 32 (Pt3): 485–8.
doi:
10.1042/BST0320485.
PMID15157167.
Han S, Stuart LA, Degen SJ (1991). "Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor". Biochemistry. 30 (40): 9768–80.
doi:
10.1021/bi00104a029.
PMID1655021.
Schultz SJ, Nigg EA (1993). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30.
PMID8274451.
Creasy CL, Chernoff J (1995). "Cloning and characterization of a member of the MST subfamily of Ste20-like kinases". Gene. 167 (1–2): 303–6.
doi:
10.1016/0378-1119(95)00653-2.
PMID8566796.