From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
52 kDa repressor of the inhibitor of the protein kinase is an
enzyme that in humans is encoded by the PRKRIR
gene .
[4]
[5]
PRKRIR has been shown to
interact with
STK4
[6] and
DNAJC3 .
[4]
Mellor H, Proud CG (1991). "A synthetic peptide substrate for initiation factor-2 kinases". Biochem. Biophys. Res. Commun . 178 (2): 430–7.
doi :
10.1016/0006-291X(91)90125-Q .
PMID
1677563 .
Polyak SJ, Tang N, Wambach M, et al. (1996).
"The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity" . J. Biol. Chem . 271 (3): 1702–7.
doi :
10.1074/jbc.271.3.1702 .
PMID
8576172 .
Shi Y, Vattem KM, Sood R, et al. (1998).
"Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control" . Mol. Cell. Biol . 18 (12): 7499–509.
doi :
10.1128/MCB.18.12.7499 .
PMC
109330 .
PMID
9819435 .
Lu J, O'Hara EB, Trieselmann BA, et al. (1999).
"The interferon-induced double-stranded RNA-activated protein kinase PKR will phosphorylate serine, threonine, or tyrosine at residue 51 in eukaryotic initiation factor 2alpha" . J. Biol. Chem . 274 (45): 32198–203.
doi :
10.1074/jbc.274.45.32198 .
PMID
10542257 .
Saelens X, Kalai M, Vandenabeele P (2001).
"Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation" . J. Biol. Chem . 276 (45): 41620–8.
doi :
10.1074/jbc.M103674200 .
PMID
11555640 .
Lin Y, Khokhlatchev A, Figeys D, Avruch J (2003).
"Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis" . J. Biol. Chem . 277 (50): 47991–8001.
doi :
10.1074/jbc.M202630200 .
PMID
12384512 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Lee JH, Choi SR, Hwang TH, et al. (2004). "A gene expression in study human gastric adenocarcinoma using a cDNA microarray". The Korean Journal of Gastroenterology = Taehan Sohwagi Hakhoe Chi . 42 (6): 484–95.
PMID
14695705 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8.
Bibcode :
2005Natur.437.1173R .
doi :
10.1038/nature04209 .
PMID
16189514 .
S2CID
4427026 .