Mitogen-activated protein kinase kinase kinase 8 is an
enzyme that in humans is encoded by the MAP3K8gene.[5][6][7]
Function
The gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the
serine/threonine-specific protein kinase family. This kinase can activate
ERK1,
ERK2 and
p38 MAP kinases.[8][9] This kinase was shown to activate
IkappaB kinases, and thus induce the nuclear production of
NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1, p105 (NFKB1). This gene may also start transcription at a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity.[7] In mice, the gene is known as TPL2 and is a tumor-suppressor gene whose absence contributes to the development and progression of cancer.[10] However, it functions in other organs as a oncogene, promoting cancer.[11]
Aoki M, Akiyama T, Miyoshi J, Toyoshima K (Sep 1991). "Identification and characterization of protein products of the cot oncogene with serine kinase activity". Oncogene. 6 (9): 1515–9.
PMID1833717.
Mitogen-activated protein kinase kinase kinase 8 is an
enzyme that in humans is encoded by the MAP3K8gene.[5][6][7]
Function
The gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the
serine/threonine-specific protein kinase family. This kinase can activate
ERK1,
ERK2 and
p38 MAP kinases.[8][9] This kinase was shown to activate
IkappaB kinases, and thus induce the nuclear production of
NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1, p105 (NFKB1). This gene may also start transcription at a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity.[7] In mice, the gene is known as TPL2 and is a tumor-suppressor gene whose absence contributes to the development and progression of cancer.[10] However, it functions in other organs as a oncogene, promoting cancer.[11]
Aoki M, Akiyama T, Miyoshi J, Toyoshima K (Sep 1991). "Identification and characterization of protein products of the cot oncogene with serine kinase activity". Oncogene. 6 (9): 1515–9.
PMID1833717.