Mitogen-activated protein kinase 11 is an
enzyme that in humans is encoded by the MAPK11gene.[5][6]
Function
The protein encoded by this gene is a member of the
MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as
proliferation,
differentiation,
transcription regulation, and development. This kinase is most closely related to
p38 MAP kinase, both of which can be activated by proinflammatory
cytokines and environmental stress. This kinase is activated through its phosphorylation by
MAP kinase kinases (
MKKs), preferably by
MKK6.
Transcription factorATF2/CREB2 has been shown to be a substrate of this kinase.[6]
Naderi J, Hung M, Pandey S (2003). "Oxidative stress-induced apoptosis in dividing fibroblasts involves activation of p38 MAP kinase and over-expression of Bax: resistance of quiescent cells to oxidative stress". Apoptosis. 8 (1): 91–100.
doi:
10.1023/A:1021657220843.
PMID12510156.
S2CID19686042.
Stringaris AK, Geisenhainer J, Bergmann F, Balshüsemann C, Lee U, Zysk G, Mitchell TJ, Keller BU, Kuhnt U, Gerber J, Spreer A, Bähr M, Michel U, Nau R (2002). "Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein kinase". Neurobiol. Dis. 11 (3): 355–68.
doi:
10.1006/nbdi.2002.0561.
hdl:11858/00-001M-0000-0012-F282-1.
PMID12586546.
S2CID25034287.
Mitogen-activated protein kinase 11 is an
enzyme that in humans is encoded by the MAPK11gene.[5][6]
Function
The protein encoded by this gene is a member of the
MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as
proliferation,
differentiation,
transcription regulation, and development. This kinase is most closely related to
p38 MAP kinase, both of which can be activated by proinflammatory
cytokines and environmental stress. This kinase is activated through its phosphorylation by
MAP kinase kinases (
MKKs), preferably by
MKK6.
Transcription factorATF2/CREB2 has been shown to be a substrate of this kinase.[6]
Naderi J, Hung M, Pandey S (2003). "Oxidative stress-induced apoptosis in dividing fibroblasts involves activation of p38 MAP kinase and over-expression of Bax: resistance of quiescent cells to oxidative stress". Apoptosis. 8 (1): 91–100.
doi:
10.1023/A:1021657220843.
PMID12510156.
S2CID19686042.
Stringaris AK, Geisenhainer J, Bergmann F, Balshüsemann C, Lee U, Zysk G, Mitchell TJ, Keller BU, Kuhnt U, Gerber J, Spreer A, Bähr M, Michel U, Nau R (2002). "Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein kinase". Neurobiol. Dis. 11 (3): 355–68.
doi:
10.1006/nbdi.2002.0561.
hdl:11858/00-001M-0000-0012-F282-1.
PMID12586546.
S2CID25034287.