Serine/threonine-protein kinase 10 is an
enzyme that in humans is encoded by the STK10gene.[5][6]
This gene encodes a member of the Ste20 family of
serine/threonine protein kinases, and is similar to several known
polo-like kinase kinases. The
protein can associate with and phosphorylate
polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal
cell cycle progression. The
kinase can also negatively regulate
interleukin 2 expression in
T-cells via the mitogen activated protein kinase kinase 1 pathway.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kuramochi S, Matsuda Y, Okamoto M, Kitamura F, Yonekawa H, Karasuyama H (Jun 1999). "Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues". Immunogenetics. 49 (5): 369–75.
doi:
10.1007/s002510050509.
PMID10199912.
S2CID877572.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92.
doi:
10.1038/nbt1240.
PMID16964243.
S2CID14294292.
Serine/threonine-protein kinase 10 is an
enzyme that in humans is encoded by the STK10gene.[5][6]
This gene encodes a member of the Ste20 family of
serine/threonine protein kinases, and is similar to several known
polo-like kinase kinases. The
protein can associate with and phosphorylate
polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal
cell cycle progression. The
kinase can also negatively regulate
interleukin 2 expression in
T-cells via the mitogen activated protein kinase kinase 1 pathway.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kuramochi S, Matsuda Y, Okamoto M, Kitamura F, Yonekawa H, Karasuyama H (Jun 1999). "Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues". Immunogenetics. 49 (5): 369–75.
doi:
10.1007/s002510050509.
PMID10199912.
S2CID877572.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92.
doi:
10.1038/nbt1240.
PMID16964243.
S2CID14294292.