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Identifiers | |
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PubChem CID | |
ChemSpider | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C24H25NO3 |
Molar mass | 375.468 g·mol−1 |
3D model ( JSmol) | |
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(verify) |
N-Phenethylnormorphine is an opioid analgesic drug derived from morphine by replacing the N-methyl group with β-phenethyl. [1] It is around eight to fourteen times more potent than morphine as a result of this modification, [2] in contrast to most other N-substituted derivatives of morphine, which are substantially less active, or act as antagonists. [3] Binding studies have helped to explain the increased potency of N-phenethylnormorphine, showing that the phenethyl group extends out to reach an additional binding point deeper inside the μ-opioid receptor cleft, analogous to the binding of the phenethyl group on fentanyl. [4] [5]
![]() | |
Identifiers | |
---|---|
| |
PubChem CID | |
ChemSpider | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C24H25NO3 |
Molar mass | 375.468 g·mol−1 |
3D model ( JSmol) | |
| |
| |
(verify) |
N-Phenethylnormorphine is an opioid analgesic drug derived from morphine by replacing the N-methyl group with β-phenethyl. [1] It is around eight to fourteen times more potent than morphine as a result of this modification, [2] in contrast to most other N-substituted derivatives of morphine, which are substantially less active, or act as antagonists. [3] Binding studies have helped to explain the increased potency of N-phenethylnormorphine, showing that the phenethyl group extends out to reach an additional binding point deeper inside the μ-opioid receptor cleft, analogous to the binding of the phenethyl group on fentanyl. [4] [5]