From Wikipedia, the free encyclopedia
T-cell growth factors acronym: TCGF(s) are signaling molecules collectively called
growth factors which stimulate the production and development of
T-cells . A number of them have been discovered, among them many members of the
interleukin family. The
thymus is one organ which releases TCGFs. TCGFs have been able to induce T-cell production outside the body for injection.
^ Oppenheim, Joost J. (August 1, 2007).
"IL-2: More Than a T Cell Growth Factor" . The Journal of Immunology . 179 (3): 1413–1414.
doi :
10.4049/jimmunol.179.3.1413 .
PMID
17641004 – via www.jimmunol.org.
^ Chazen, G D; Pereira, G M; LeGros, G; Gillis, S; Shevach, E M (1989).
"Interleukin 7 is a T-cell growth factor" . Proceedings of the National Academy of Sciences of the United States of America . 86 (15): 5923–5927.
Bibcode :
1989PNAS...86.5923C .
doi :
10.1073/pnas.86.15.5923 .
ISSN
0027-8424 .
PMC
297743 .
PMID
2788279 .
^
"Jena Bioscience - Products & Ordering - Recombinant Proteins - Cytokines and Growth Factors - T-Cell Growth Factors" . www.jenabioscience.com . Archived from
the original on 2007-11-14.
^ Steel, JC; Waldmann, TA; Morris, JC (January 2012).
"Interleukin-15 biology and its therapeutic implications in cancer" . Trends Pharmacol. Sci . 33 (1): 35–41.
doi :
10.1016/j.tips.2011.09.004 .
PMC
3327885 .
PMID
22032984 .
By family
By function/ cell
Angiopoietin
CNTF
EGF (ErbB)
FGF
FGFR1
FGFR2
Agonists:
Ersofermin
FGF (
1 ,
2 (bFGF) ,
3 ,
4 ,
5 ,
6 ,
7 (
KGF ),
8 ,
9 ,
10 (KGF2) ,
17 ,
18 ,
22 )
Palifermin
Repifermin
Selpercatinib
Sprifermin
Trafermin
FGFR3
FGFR4 Unsorted
HGF (c-Met)
IGF
LNGF (p75NTR )
PDGF
RET (GFL)
SCF (c-Kit)
TGFβ
Trk
TrkA
Negative allosteric modulators:
VM-902A
TrkB
Agonists:
3,7-DHF
3,7,8,2'-THF
4'-DMA-7,8-DHF
7,3'-DHF
7,8-DHF
7,8,2'-THF
7,8,3'-THF
Amitriptyline
BDNF
BNN-20
Deoxygedunin
Deprenyl
Diosmetin
DMAQ-B1
HIOC
LM22A-4
N-Acetylserotonin
NT-3
NT-4
Norwogonin (5,7,8-THF)
R7
R13
TDP6
TrkC
VEGF Others
Additional growth factors:
Adrenomedullin
Colony-stimulating factors (see
here instead)
Connective tissue growth factor (CTGF)
Ephrins (
A1 ,
A2 ,
A3 ,
A4 ,
A5 ,
B1 ,
B2 ,
B3 )
Erythropoietin (see
here instead)
Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
Glia maturation factor (GMF)
Hepatoma-derived growth factor (HDGF)
Interleukins /
T-cell growth factors (see
here instead)
Leukemia inhibitory factor (LIF)
Macrophage-stimulating protein (MSP; HLP, HGFLP)
Midkine (NEGF2)
Migration-stimulating factor (MSF; PRG4)
Oncomodulin
Pituitary adenylate cyclase-activating peptide (PACAP)
Pleiotrophin
Renalase
Thrombopoietin (see
here instead)
Wnt signaling proteins
Additional growth factor receptor modulators:
Cerebrolysin (neurotrophin mixture)
Chemokine
CSF
Interferon
IFNAR (α/β, I)
Agonists:
Albinterferon
Interferon alpha (interferon alfa, IFN-α)
Interferon alfa (
IFNA1 ,
IFNA2 ,
IFNA4 ,
IFNA5 ,
IFNA6 ,
IFNA7 ,
IFNA8 ,
IFNA10 ,
IFNA13 ,
IFNA14 ,
IFNA16 ,
IFNA17 ,
IFNA21 )
Interferon alfa 2a
Interferon alfa 2b
Interferon alfa n1
Interferon alfacon-1
Interferon alpha-n3
Interferon beta (IFN-β) (
IFNB1 ,
IFNB3 )
Interferon beta 1a
Interferon beta 1b
Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
Interferon omega (IFN-ω, IFNW1)
Peginterferon alfa-2a
Peginterferon alfa-2b
IFNGR (γ, II)
IFNLR (λ, III)
See IL-28R (IFNLR)
here instead.
Interleukin
TGFβ
TNF Others