Chemokine (C-C motif) ligand 19 (CCL19) is a
protein that in humans is encoded by the CCL19gene.[5][6]
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor
CCR7.[6]
Chemokine (C-C motif) ligand 19 (CCL19) is a small
cytokine belonging to the CC
chemokine family that is also known as EBI1 ligand chemokine (ELC) and macrophage inflammatory protein-3-beta (MIP-3-beta). CCL19 is expressed abundantly in
thymus and
lymph nodes, with moderate levels in
trachea and
colon and low levels in stomach,
small intestine,
lung,
kidney and
spleen.[7] The gene for CCL19 is located on human
chromosome 9.[8] This chemokine elicits its effects on its target cells by binding to the chemokine receptor
chemokine receptorCCR7.[7] It attracts certain cells of the
immune system, including
dendritic cells and antigen-engaged
B cells,[9][10]CCR7+ central-memory T-Cells.[11]
Katou F, Ohtani H, Nakayama T, et al. (2003). "Differential expression of CCL19 by DC-Lamp+ mature dendritic cells in human lymph node versus chronically inflamed skin". J. Pathol. 199 (1): 98–106.
doi:
10.1002/path.1255.
PMID12474232.
S2CID25424987.
Corcione A, Arduino N, Ferretti E, et al. (2004). "CCL19 and CXCL12 trigger in vitro chemotaxis of human mantle cell lymphoma B cells". Clin. Cancer Res. 10 (3): 964–71.
doi:
10.1158/1078-0432.CCR-1182-3.
PMID14871974.
S2CID9041635.
Chemokine (C-C motif) ligand 19 (CCL19) is a
protein that in humans is encoded by the CCL19gene.[5][6]
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor
CCR7.[6]
Chemokine (C-C motif) ligand 19 (CCL19) is a small
cytokine belonging to the CC
chemokine family that is also known as EBI1 ligand chemokine (ELC) and macrophage inflammatory protein-3-beta (MIP-3-beta). CCL19 is expressed abundantly in
thymus and
lymph nodes, with moderate levels in
trachea and
colon and low levels in stomach,
small intestine,
lung,
kidney and
spleen.[7] The gene for CCL19 is located on human
chromosome 9.[8] This chemokine elicits its effects on its target cells by binding to the chemokine receptor
chemokine receptorCCR7.[7] It attracts certain cells of the
immune system, including
dendritic cells and antigen-engaged
B cells,[9][10]CCR7+ central-memory T-Cells.[11]
Katou F, Ohtani H, Nakayama T, et al. (2003). "Differential expression of CCL19 by DC-Lamp+ mature dendritic cells in human lymph node versus chronically inflamed skin". J. Pathol. 199 (1): 98–106.
doi:
10.1002/path.1255.
PMID12474232.
S2CID25424987.
Corcione A, Arduino N, Ferretti E, et al. (2004). "CCL19 and CXCL12 trigger in vitro chemotaxis of human mantle cell lymphoma B cells". Clin. Cancer Res. 10 (3): 964–71.
doi:
10.1158/1078-0432.CCR-1182-3.
PMID14871974.
S2CID9041635.