Chemokine (C-C motif) ligand 8 (CCL8), also known as monocyte chemoattractant protein 2 (MCP2), is a
protein that in humans is encoded by the CCL8gene.[3][4]
CCL8 is a CC chemokine that utilizes multiple cellular receptors to attract and activate human leukocytes. CCL8 is a potent inhibitor of
HIV1 by virtue of its high-affinity binding to the receptor CCR5, one of the major co-receptors for HIV1.[9] In addition, CCL8 attributes to the growth of metastasis in breast cancer cells. The manipulation of this chemokine activity influences the histology of tumors promoting steps of metastatic processes.[10] CCL8 is also involved in attracting macrophages to the decidua in labor.[11]
^
abVan Coillie E, Fiten P, Nomiyama H, Sakaki Y, Miura R, Yoshie O, Van Damme J, Opdenakker G (March 1997). "The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2". Genomics. 40 (2): 323–31.
doi:
10.1006/geno.1996.4594.
PMID9119400.
Struyf S, Proost P, Vandercappellen J, et al. (2009). "Synergistic up-regulation of MCP-2/CCL8 activity is counteracted by chemokine cleavage, limiting its inflammatory and anti-tumoral effects". Eur. J. Immunol. 39 (3): 843–57.
doi:
10.1002/eji.200838660.
PMID19224633.
S2CID41872921.
Villa C, Venturelli E, Fenoglio C, et al. (2009). "CCL8/MCP-2 association analysis in patients with Alzheimer's disease and frontotemporal lobar degeneration". J. Neurol. 256 (8): 1379–81.
doi:
10.1007/s00415-009-5138-y.
PMID19415413.
S2CID3147096.
Schuurhof A, Bont L, Siezen CL, et al. (2010). "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls". Pediatr. Pulmonol. 45 (6): 608–13.
doi:
10.1002/ppul.21229.
PMID20503287.
S2CID24678182.
Chemokine (C-C motif) ligand 8 (CCL8), also known as monocyte chemoattractant protein 2 (MCP2), is a
protein that in humans is encoded by the CCL8gene.[3][4]
CCL8 is a CC chemokine that utilizes multiple cellular receptors to attract and activate human leukocytes. CCL8 is a potent inhibitor of
HIV1 by virtue of its high-affinity binding to the receptor CCR5, one of the major co-receptors for HIV1.[9] In addition, CCL8 attributes to the growth of metastasis in breast cancer cells. The manipulation of this chemokine activity influences the histology of tumors promoting steps of metastatic processes.[10] CCL8 is also involved in attracting macrophages to the decidua in labor.[11]
^
abVan Coillie E, Fiten P, Nomiyama H, Sakaki Y, Miura R, Yoshie O, Van Damme J, Opdenakker G (March 1997). "The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2". Genomics. 40 (2): 323–31.
doi:
10.1006/geno.1996.4594.
PMID9119400.
Struyf S, Proost P, Vandercappellen J, et al. (2009). "Synergistic up-regulation of MCP-2/CCL8 activity is counteracted by chemokine cleavage, limiting its inflammatory and anti-tumoral effects". Eur. J. Immunol. 39 (3): 843–57.
doi:
10.1002/eji.200838660.
PMID19224633.
S2CID41872921.
Villa C, Venturelli E, Fenoglio C, et al. (2009). "CCL8/MCP-2 association analysis in patients with Alzheimer's disease and frontotemporal lobar degeneration". J. Neurol. 256 (8): 1379–81.
doi:
10.1007/s00415-009-5138-y.
PMID19415413.
S2CID3147096.
Schuurhof A, Bont L, Siezen CL, et al. (2010). "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls". Pediatr. Pulmonol. 45 (6): 608–13.
doi:
10.1002/ppul.21229.
PMID20503287.
S2CID24678182.