Chemokine (C-X-C motif) ligand 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) or B cell-attracting chemokine 1 (BCA-1), is a protein ligand that in humans is encoded by the CXCL13 gene. [5] [6]
CXCL13 is a small chemokine belonging to the CXC chemokine family. As its other names suggest, this chemokine is selectively chemotactic for B cells belonging to both the B-1 and B-2 subsets, and elicits its effects by interacting with chemokine receptor CXCR5. [5] [7] CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues [8] and is expressed highly in the liver, spleen, lymph nodes, and gut of humans. [5] The gene for CXCL13 is located on human chromosome 4 in a cluster of other CXC chemokines. [6]
In T lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T cell, particularly a subset of T cells called follicular B helper T cells (or TFH cells). Hence, expression of CXCL13 in T-cell lymphomas, such as angioimmunoblastic T-cell lymphoma, is thought to reflect a germinal center origin of the neoplastic T-cells. [9]
CXCL13 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | CXCL13, ANGIE, ANGIE2, BCA-1, BCA1, BLC, BLR1L, SCYB13, C-X-C motif chemokine ligand 13 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 605149; MGI: 1888499; HomoloGene: 48431; GeneCards: CXCL13; OMA: CXCL13 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Chemokine (C-X-C motif) ligand 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) or B cell-attracting chemokine 1 (BCA-1), is a protein ligand that in humans is encoded by the CXCL13 gene. [5] [6]
CXCL13 is a small chemokine belonging to the CXC chemokine family. As its other names suggest, this chemokine is selectively chemotactic for B cells belonging to both the B-1 and B-2 subsets, and elicits its effects by interacting with chemokine receptor CXCR5. [5] [7] CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues [8] and is expressed highly in the liver, spleen, lymph nodes, and gut of humans. [5] The gene for CXCL13 is located on human chromosome 4 in a cluster of other CXC chemokines. [6]
In T lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T cell, particularly a subset of T cells called follicular B helper T cells (or TFH cells). Hence, expression of CXCL13 in T-cell lymphomas, such as angioimmunoblastic T-cell lymphoma, is thought to reflect a germinal center origin of the neoplastic T-cells. [9]