chemokine (C-X-C motif) ligand 14 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | CXCL14 | ||||||
Alt. symbols | SCYB14, BRAK, NJAC, bolekine, Kec, MIP-2g, BMAC, KS1 | ||||||
NCBI gene | 9547 | ||||||
HGNC | 10640 | ||||||
OMIM | 604186 | ||||||
PDB | 2HDL | ||||||
RefSeq | NM_004887 | ||||||
UniProt | O95715 | ||||||
Other data | |||||||
Locus | Chr. 5 q31 | ||||||
|
Chemokine (C-X-C motif) ligand 14 (CXCL14) is a small cytokine belonging to the CXC chemokine family that is also known as BRAK (for breast and kidney-expressed chemokine). [1] Mature CXCL14 has many of the conserved features of the CXC chemokine subfamily but has some differences too, such as a shorter N-terminus and five extra amino acids in the region between its third and fourth cysteines. [1] CXCL14 is constitutively expressed at high levels in many normal tissues, where its cellular source is thought to be fibroblasts. [2] However, it is reduced or absent from most cancer cells. [1] [3] This chemokine is chemotactic for monocytes and can activate these cells in the presence of an inflammatory mediator called prostaglandin-E2 (PGE2). [2] It is also a potent chemoattractant and activator of dendritic cells, is implicated in homing of these cells, [4] and can stimulate the migration of activated NK cells. [5] CXCL14 also inhibits angiogenesis, possibly as a result of its ability to block endothelial cell chemotaxis. [6] The gene for CXCL14 contains four exons and is located on chromosome 5 in humans. [1]
chemokine (C-X-C motif) ligand 14 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | CXCL14 | ||||||
Alt. symbols | SCYB14, BRAK, NJAC, bolekine, Kec, MIP-2g, BMAC, KS1 | ||||||
NCBI gene | 9547 | ||||||
HGNC | 10640 | ||||||
OMIM | 604186 | ||||||
PDB | 2HDL | ||||||
RefSeq | NM_004887 | ||||||
UniProt | O95715 | ||||||
Other data | |||||||
Locus | Chr. 5 q31 | ||||||
|
Chemokine (C-X-C motif) ligand 14 (CXCL14) is a small cytokine belonging to the CXC chemokine family that is also known as BRAK (for breast and kidney-expressed chemokine). [1] Mature CXCL14 has many of the conserved features of the CXC chemokine subfamily but has some differences too, such as a shorter N-terminus and five extra amino acids in the region between its third and fourth cysteines. [1] CXCL14 is constitutively expressed at high levels in many normal tissues, where its cellular source is thought to be fibroblasts. [2] However, it is reduced or absent from most cancer cells. [1] [3] This chemokine is chemotactic for monocytes and can activate these cells in the presence of an inflammatory mediator called prostaglandin-E2 (PGE2). [2] It is also a potent chemoattractant and activator of dendritic cells, is implicated in homing of these cells, [4] and can stimulate the migration of activated NK cells. [5] CXCL14 also inhibits angiogenesis, possibly as a result of its ability to block endothelial cell chemotaxis. [6] The gene for CXCL14 contains four exons and is located on chromosome 5 in humans. [1]