From Wikipedia, the free encyclopedia
Chemical compound
Peficitinib
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Trade names | Smyraf |
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Other names | ASP015K; JNJ-54781532 |
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ATC code | |
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Legal status |
- In general: ℞ (Prescription only)
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CAS Number | |
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PubChem
CID | |
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UNII | |
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KEGG | |
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Formula | C18H22N4O2 |
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Molar mass | 326.400 g·mol−1 |
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3D model (
JSmol) | |
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NC(=O)c1cnc2[nH]ccc2c1NC1[C@H]2CC3C[C@@H]1CC(O)(C3)C2
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InChI=1S/C18H22N4O2/c19-16(23)13-8-21-17-12(1-2-20-17)15(13)22-14-10-3-9-4-11(14)7-18(24,5-9)6-10/h1-2,8-11,14,24H,3-7H2,(H2,19,23)(H2,20,21,22)/t9?,10-,11+,1 YKey:DREIJXJRTLTGJC-JQCLMNFQSA-N Y
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Peficitinib (brand name Smyraf) is a pharmaceutical drug used for the treatment of
rheumatoid arthritis. It belongs to the class of drugs known as
Janus kinase inhibitors (JAK inhibitors).
[1]
[2]
Peficitinib was approved for use in Japan in 2019.
[3]
References
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^ Kivitz AJ, Gutierrez-Ureña SR, Poiley J, Genovese MC, Kristy R, Shay K, et al. (April 2017).
"Peficitinib, a JAK Inhibitor, in the Treatment of Moderate-to-Severe Rheumatoid Arthritis in Patients With an Inadequate Response to Methotrexate". Arthritis & Rheumatology. 69 (4): 709–719.
doi:
10.1002/art.39955.
PMID
27748083.
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^ Genovese MC, Greenwald M, Codding C, Zubrzycka-Sienkiewicz A, Kivitz AJ, Wang A, et al. (May 2017).
"Peficitinib, a JAK Inhibitor, in Combination With Limited Conventional Synthetic Disease-Modifying Antirheumatic Drugs in the Treatment of Moderate-to-Severe Rheumatoid Arthritis". Arthritis & Rheumatology. 69 (5): 932–942.
doi:
10.1002/art.40054.
PMID
28118538.
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^ Markham A, Keam SJ (June 2019). "Peficitinib: First Global Approval". Drugs. 79 (8): 887–891.
doi:
10.1007/s40265-019-01131-y.
PMID
31093950.
S2CID
155093525.
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Chemokine | |
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CSF | |
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Interferon |
IFNAR (α/β, I) |
- Agonists:
Albinterferon
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Interferon alpha (interferon alfa, IFN-α)
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Interferon alfa (
IFNA1,
IFNA2,
IFNA4,
IFNA5,
IFNA6,
IFNA7,
IFNA8,
IFNA10,
IFNA13,
IFNA14,
IFNA16,
IFNA17,
IFNA21)
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Interferon alfa 2a
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Interferon alfa 2b
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Interferon alfa n1
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Interferon alfacon-1
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Interferon alpha-n3
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Interferon beta (IFN-β) (
IFNB1,
IFNB3)
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Interferon beta 1a
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Interferon beta 1b
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Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
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Interferon omega (IFN-ω, IFNW1)
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Peginterferon alfa-2a
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Peginterferon alfa-2b
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IFNGR (γ, II) | |
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IFNLR (λ, III) |
- See IL-28R (IFNLR)
here instead.
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Interleukin | |
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TGFβ | |
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TNF | |
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Others | |
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