HEPATOMA-DERIVED GROWTH FACTOR

HDGF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1RI0, 2NLU
Identifiers
Aliases	HDGF, HMG1L2, hepatoma-derived growth factor, heparin binding growth factor
External IDs	OMIM: 600339; MGI: 1194494; HomoloGene: 3306; GeneCards: HDGF; OMA: HDGF - orthologs
Gene location ( Human)
Chr.	Chromosome 1 (human)
End	156,766,925 bp
Gene location ( Mouse)
Chr.	Chromosome 3 (mouse)
End	87,823,439 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; mucosa of ileum; ; olfactory zone of nasal mucosa; ; mucosa of transverse colon; ; right uterine tube; ; rectum; ; skin of leg; ; gastrocnemius muscle; ; skin of abdomen;
	Top expressed in
	otic placode; ; otic vesicle; ; saccule; ; Ileal epithelium; ; fetal liver hematopoietic progenitor cell; ; epiblast; ; lactiferous gland; ; ventricular zone; ; lip; ; yolk sac;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; DNA binding; transcription corepressor binding; transcription corepressor activity; growth factor activity; heparin binding; RNA binding;
Cellular component	cytoplasm; transcription repressor complex; nucleus; nucleoplasm; extracellular space; extracellular matrix; extracellular region; collagen-containing extracellular matrix;
Biological process	IRE1-mediated unfolded protein response; cell population proliferation; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; signal transduction; cellular process; regulation of signaling receptor activity; cellular response to interleukin-7;
	Sources: Amigo / QuickGO
Orthologs
	3068
	15191
	ENSG00000143321
	ENSMUSG00000004897
	P51858
	P51859
NM_001126050; NM_001126051; NM_004494; NM_001319186; NM_001319187;
	NM_001319188
	NM_008231; NM_001331051; NM_001331052
NP_001119522; NP_001119523; NP_001306115; NP_001306116; NP_001306117;
	NP_004485
	NP_001317980; NP_001317981; NP_032257
	Wikidata
View/Edit Human	View/Edit Mouse

Hepatoma-derived growth factor (HDGF) also known as high mobility group protein 1-like 2 (HMG-1L2) is a protein that in humans is encoded by the HDGF gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143321 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004897 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wanschura S, Schoenmakers EF, Huysmans C, Bartnitzke S, Van de Ven WJ, Bullerdiek J (May 1997). "Mapping of the gene encoding the human hepatoma-derived growth factor (HDGF) with homology to the high-mobility group (HMG)-1 protein to Xq25". Genomics. 32 (2): 298–300. doi: 10.1006/geno.1996.0122. PMID 8833162.
^ "Entrez Gene: HDGF hepatoma-derived growth factor (high-mobility group protein 1-like)".

Everett AD, Bushweller J (2003). "Hepatoma derived growth factor is a nuclear targeted mitogen". Current Drug Targets. 4 (5): 367–71. doi: 10.2174/1389450033490975. PMID 12816346.
Nakamura H, Izumoto Y, Kambe H, et al. (1994). "Molecular cloning of complementary DNA for a novel human hepatoma-derived growth factor. Its homology with high mobility group-1 protein". J. Biol. Chem. 269 (40): 25143–9. doi: 10.1016/S0021-9258(17)31509-0. PMID 7929202.
Kishima Y, Yamamoto H, Izumoto Y, et al. (2002). "Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus by nuclear localization signals". J. Biol. Chem. 277 (12): 10315–22. doi: 10.1074/jbc.M111122200. PMID 11751870.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mori M, Morishita H, Nakamura H, et al. (2004). "Hepatoma-derived growth factor is involved in lung remodeling by stimulating epithelial growth". Am. J. Respir. Cell Mol. Biol. 30 (4): 459–69. doi: 10.1165/rcmb.2003-0013OC. PMID 12972397.
Yoshida K, Nakamura H, Okuda Y, et al. (2004). "Expression of hepatoma-derived growth factor in hepatocarcinogenesis". J. Gastroenterol. Hepatol. 18 (11): 1293–301. doi: 10.1046/j.1440-1746.2003.03191.x. PMID 14535987. S2CID 24881855.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285. PMID 14702039.
Shu H, Chen S, Bi Q, et al. (2004). "Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line". Mol. Cell. Proteomics. 3 (3): 279–86. doi: 10.1074/mcp.D300003-MCP200. PMID 14729942.
Everett AD, Narron JV, Stoops T, et al. (2004). "Hepatoma-derived growth factor is a pulmonary endothelial cell-expressed angiogenic factor". Am. J. Physiol. Lung Cell Mol. Physiol. 286 (6): L1194–201. doi: 10.1152/ajplung.00427.2003. PMID 14751852. S2CID 17651256.
Sue SC, Chen JY, Huang TH (2004). "Sequence specific 1H, 13C and 15N resonance assignments of the hath-domain of human hepatoma-derived growth factor". J. Biomol. NMR. 29 (1): 95–6. doi: 10.1023/B:JNMR.0000019467.57276.05. PMID 15017145. S2CID 84545598.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode: 2004PNAS..10112130B. doi: 10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200. PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
Shen XY, Zacal N, Singh G, Rainbow AJ (2005). "Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT29 colon carcinoma cells". Photochem. Photobiol. 81 (2): 306–13. doi: 10.1562/2004-07-22-RA-242. PMID 15560738.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode: 2005Sci...307.1621B. doi: 10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Iwasaki T, Nakagawa K, Nakamura H, et al. (2005). "Hepatoma-derived growth factor as a prognostic marker in completely resected non-small-cell lung cancer". Oncol. Rep. 13 (6): 1075–80. doi: 10.3892/or.13.6.1075. PMID 15870924.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode: 2006Natur.441..315G. doi: 10.1038/nature04727. PMID 16710414.
Beranova-Giorgianni S, Zhao Y, Desiderio DM, Giorgianni F (2006). "Phosphoproteomic analysis of the human pituitary". Pituitary. 9 (2): 109–20. doi: 10.1007/s11102-006-8916-x. PMID 16807684. S2CID 10789246.
Clermont F, Gonzalez NS, Communi D, Franken S, Dumont JE, Robaye B (2008). "HDGF is dephosphorylated during the early steps of endothelial cell apoptosis in a caspase-dependent way". J Cell Biochem. 104 (4): 1161–1171. doi: 10.1002/jcb.21788. PMID 18465786. S2CID 8154321.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Hepatoma-derived growth factor

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143321 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004897 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8833162-5] Wanschura S, Schoenmakers EF, Huysmans C, Bartnitzke S, Van de Ven WJ, Bullerdiek J (May 1997). "Mapping of the gene encoding the human hepatoma-derived growth factor (HDGF) with homology to the high-mobility group (HMG)-1 protein to Xq25". Genomics. 32 (2): 298–300. doi: 10.1006/geno.1996.0122. PMID 8833162.

[entrez-6] "Entrez Gene: HDGF hepatoma-derived growth factor (high-mobility group protein 1-like)".

[1]

[2]

[3]

[4]

[5]

[6]

References

Further reading

External links

References

Further reading

External links

Videos

Websites

Encyclopedia

Facebook