From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
"NRG4" redirects here. For the cannabinoid drug, see
RCS-4 .
Neuregulin 4 also known as NRG4 is a member of the
neuregulin
protein family which in humans is encoded by the NRG4
gene .
[5]
[6]
[7]
The neuregulins, including NRG4, activate erb-b2 receptor tyrosine kinase 4 (
ERBB4 ) to initiating cell signaling through cytosolic tyrosine phosphorylation.
[7]
Loss of expression of NRG4 is frequently seen in advanced
bladder cancer while increased NRG4 expression correlates to better survival.
[8]
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000169752 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000032311 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Entrez Gene: NRG4 neuregulin 4" .
^ Strausberg RL, Feingold EA, Grouse LH, et al. (December 2002).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
^
a
b Harari D, Tzahar E, Romano J, Shelly M, Pierce JH, Andrews GC, Yarden Y (April 1999).
"Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase" . Oncogene . 18 (17): 2681–9.
doi :
10.1038/sj.onc.1202631 .
PMID
10348342 .
^ Memon AA, Sorensen BS, Melgard P, Fokdal L, Thykjaer T, Nexo E (December 2004).
"Expression of HER3, HER4 and their ligand heregulin-4 is associated with better survival in bladder cancer patients" . Br. J. Cancer . 91 (12): 2034–41.
doi :
10.1038/sj.bjc.6602251 .
PMC
2409781 .
PMID
15583696 .
Révillion F, Lhotellier V, Hornez L, Bonneterre J, Peyrat JP (January 2008).
"ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis" . Ann. Oncol . 19 (1): 73–80.
doi :
10.1093/annonc/mdm431 .
PMID
17962208 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Hayes NV, Newsam RJ, Baines AJ, Gullick WJ (2008).
"Characterization of the cell membrane-associated products of the Neuregulin 4 gene" . Oncogene . 27 (5): 715–20.
doi :
10.1038/sj.onc.1210689 .
PMID
17684490 .
Hayes NV, Blackburn E, Smart LV, et al. (2007).
"Identification and characterization of novel spliced variants of neuregulin 4 in prostate cancer" . Clin. Cancer Res . 13 (11): 3147–55.
doi :
10.1158/1078-0432.CCR-06-2237 .
PMID
17545517 .
Angiopoietin
CNTF
EGF (ErbB)
FGF
FGFR1
FGFR2
Agonists:
Ersofermin
FGF (
1 ,
2 (bFGF) ,
3 ,
4 ,
5 ,
6 ,
7 (
KGF ),
8 ,
9 ,
10 (KGF2) ,
17 ,
18 ,
22 )
Palifermin
Repifermin
Selpercatinib
Sprifermin
Trafermin
FGFR3
FGFR4 Unsorted
HGF (c-Met)
IGF
LNGF (p75NTR )
PDGF
RET (GFL)
SCF (c-Kit)
TGFβ
Trk
TrkA
Negative allosteric modulators:
VM-902A
TrkB
Agonists:
3,7-DHF
3,7,8,2'-THF
4'-DMA-7,8-DHF
7,3'-DHF
7,8-DHF
7,8,2'-THF
7,8,3'-THF
Amitriptyline
BDNF
BNN-20
Deoxygedunin
Deprenyl
Diosmetin
DMAQ-B1
HIOC
LM22A-4
N-Acetylserotonin
NT-3
NT-4
Norwogonin (5,7,8-THF)
R7
R13
TDP6
TrkC
VEGF Others
Additional growth factors:
Adrenomedullin
Colony-stimulating factors (see
here instead)
Connective tissue growth factor (CTGF)
Ephrins (
A1 ,
A2 ,
A3 ,
A4 ,
A5 ,
B1 ,
B2 ,
B3 )
Erythropoietin (see
here instead)
Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
Glia maturation factor (GMF)
Hepatoma-derived growth factor (HDGF)
Interleukins /
T-cell growth factors (see
here instead)
Leukemia inhibitory factor (LIF)
Macrophage-stimulating protein (MSP; HLP, HGFLP)
Midkine (NEGF2)
Migration-stimulating factor (MSF; PRG4)
Oncomodulin
Pituitary adenylate cyclase-activating peptide (PACAP)
Pleiotrophin
Renalase
Thrombopoietin (see
here instead)
Wnt signaling proteins
Additional growth factor receptor modulators:
Cerebrolysin (neurotrophin mixture)