Fibroblast growth factor 17 is a
protein that in humans is encoded by the FGF17gene.[5][6][7]
The protein encoded by this gene is a member of the
fibroblast growth factor (FGF) family. FGF family members possess broad
mitogenic and cell survival activities and are involved in a variety of biological processes, including
embryonic development cell growth,
morphogenesis, tissue repair,
tumor growth, and invasion. This gene was shown to be prominently expressed in the
cerebellum and
cortex. The mouse
homolog of this gene was localized to specific sites in the midline structures of the
forebrain, the midbrain-hindbrain junction, developing skeleton and developing arteries, which suggests a role in
central nervous system, bone and vascular development. This gene was referred to as FGF-13 in reference 2, however, its
amino acid sequence and chromosomal localization are identical to FGF17.[7]
Xu J, Liu Z, Ornitz DM (2000). "Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures". Development. 127 (9): 1833–43.
doi:
10.1242/dev.127.9.1833.
PMID10751172.
Polnaszek N, Kwabi-Addo B, Wang J, Ittmann M (2004). "FGF17 is an autocrine prostatic epithelial growth factor and is upregulated in benign prostatic hyperplasia". Prostate. 60 (1): 18–24.
doi:
10.1002/pros.20026.
PMID15129425.
S2CID22340970.
Fibroblast growth factor 17 is a
protein that in humans is encoded by the FGF17gene.[5][6][7]
The protein encoded by this gene is a member of the
fibroblast growth factor (FGF) family. FGF family members possess broad
mitogenic and cell survival activities and are involved in a variety of biological processes, including
embryonic development cell growth,
morphogenesis, tissue repair,
tumor growth, and invasion. This gene was shown to be prominently expressed in the
cerebellum and
cortex. The mouse
homolog of this gene was localized to specific sites in the midline structures of the
forebrain, the midbrain-hindbrain junction, developing skeleton and developing arteries, which suggests a role in
central nervous system, bone and vascular development. This gene was referred to as FGF-13 in reference 2, however, its
amino acid sequence and chromosomal localization are identical to FGF17.[7]
Xu J, Liu Z, Ornitz DM (2000). "Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures". Development. 127 (9): 1833–43.
doi:
10.1242/dev.127.9.1833.
PMID10751172.
Polnaszek N, Kwabi-Addo B, Wang J, Ittmann M (2004). "FGF17 is an autocrine prostatic epithelial growth factor and is upregulated in benign prostatic hyperplasia". Prostate. 60 (1): 18–24.
doi:
10.1002/pros.20026.
PMID15129425.
S2CID22340970.