GDNF family receptor alpha-3 (GFRα3), also known as the artemin receptor, is a
protein that in humans is encoded by the GFRA3gene.[5][6]
Function
The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the
GDNF receptor family. It forms a signaling receptor complex with RET
tyrosine kinase receptor and binds the
arteminligand.[6]
In
mouse models of
osteoarthritis, GFRα3 was upregulated in sensory nerves. Treating arthritic mice with
monoclonal antibodies that bind to GFRα3 prevents artemin from binding there and signaling pain. Treated mice were able to use their limbs again two hours post-treatment.[7]
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (September 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50.
doi:
10.1006/geno.1994.1457.
PMID7829101.
GDNF family receptor alpha-3 (GFRα3), also known as the artemin receptor, is a
protein that in humans is encoded by the GFRA3gene.[5][6]
Function
The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the
GDNF receptor family. It forms a signaling receptor complex with RET
tyrosine kinase receptor and binds the
arteminligand.[6]
In
mouse models of
osteoarthritis, GFRα3 was upregulated in sensory nerves. Treating arthritic mice with
monoclonal antibodies that bind to GFRα3 prevents artemin from binding there and signaling pain. Treated mice were able to use their limbs again two hours post-treatment.[7]
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (September 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50.
doi:
10.1006/geno.1994.1457.
PMID7829101.