Ephrin-B2 is a
protein that in humans is encoded by the EFNB2gene.[5]
Function
This gene encodes a member of the
ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in
erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the
EPHB4 and
EPHA3 receptors.[6]
Cancer
EFNB2 gene has been observed progressively downregulated in
Human papillomavirus-positive
neoplastic keratinocytes derived from uterine cervical
preneoplastic lesions at different levels of malignancy.[7] For this reason, EFNB2 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical
preneoplastic lesions progression.[7]
Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annual Review of Neuroscience. 21: 309–45.
doi:
10.1146/annurev.neuro.21.1.309.
PMID9530499.
Holder N, Klein R (May 1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–44.
doi:
10.1242/dev.126.10.2033.
PMID10207129.
Vogt T, Stolz W, Welsh J, Jung B, Kerbel RS, Kobayashi H, Landthaler M, McClelland M (Mar 1998). "Overexpression of Lerk-5/Eplg5 messenger RNA: a novel marker for increased tumorigenicity and metastatic potential in human malignant melanomas". Clinical Cancer Research. 4 (3): 791–7.
PMID9533549.
Nikolova Z, Djonov V, Zuercher G, Andres AC, Ziemiecki A (Sep 1998). "Cell-type specific and estrogen dependent expression of the receptor tyrosine kinase EphB4 and its ligand ephrin-B2 during mammary gland morphogenesis". Journal of Cell Science. 111 (18): 2741–51.
doi:
10.1242/jcs.111.18.2741.
PMID9718367.
Ephrin-B2 is a
protein that in humans is encoded by the EFNB2gene.[5]
Function
This gene encodes a member of the
ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in
erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the
EPHB4 and
EPHA3 receptors.[6]
Cancer
EFNB2 gene has been observed progressively downregulated in
Human papillomavirus-positive
neoplastic keratinocytes derived from uterine cervical
preneoplastic lesions at different levels of malignancy.[7] For this reason, EFNB2 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical
preneoplastic lesions progression.[7]
Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annual Review of Neuroscience. 21: 309–45.
doi:
10.1146/annurev.neuro.21.1.309.
PMID9530499.
Holder N, Klein R (May 1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–44.
doi:
10.1242/dev.126.10.2033.
PMID10207129.
Vogt T, Stolz W, Welsh J, Jung B, Kerbel RS, Kobayashi H, Landthaler M, McClelland M (Mar 1998). "Overexpression of Lerk-5/Eplg5 messenger RNA: a novel marker for increased tumorigenicity and metastatic potential in human malignant melanomas". Clinical Cancer Research. 4 (3): 791–7.
PMID9533549.
Nikolova Z, Djonov V, Zuercher G, Andres AC, Ziemiecki A (Sep 1998). "Cell-type specific and estrogen dependent expression of the receptor tyrosine kinase EphB4 and its ligand ephrin-B2 during mammary gland morphogenesis". Journal of Cell Science. 111 (18): 2741–51.
doi:
10.1242/jcs.111.18.2741.
PMID9718367.