The adipokines, or adipocytokines (Greek adipo-, fat; cytos-, cell; and -kinos, movement) are
cytokines (
cell signalingproteins) secreted by
adipose tissue. Some contribute to an obesity-related low-grade state of inflammation or to the development of
metabolic syndrome, a constellation of diseases including, but not limited to,
type 2 diabetes,
cardiovascular disease and
atherosclerosis.[1] The first adipokine to be discovered was
leptin in 1994.[2] Since that time, hundreds of adipokines have been discovered.[3]
^Conde J, Scotece M, Gómez R, López V, Gómez-Reino JJ, Lago F, Gualillo O (2011). "Adipokines: BioFactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity". BioFactors. 37 (6): 413–420.
doi:
10.1002/biof.185.
PMID22038756.
^Lehr S, Hartwig S, Sell H (2012). "Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders". Proteomics: Clinical Applications. 6 (1–2): 91–101.
doi:
10.1002/prca.201100052.
PMID22213627.
S2CID19427071.
^Guo L, Li Q, Wang W, Yu P, Pan H, Li P, Sun Y, Zhang J. Endocr Res. 2009; 34(4):142–154.
^MacDougald1, Ormond A. and Burant, Charles F. (September 2007) "The Rapidly Expanding Family of Adipokines" Cell Metabolism 6: pp. 159–161
^Monzillo, Lais U. (2003) "Effect of Lifestyle Modification on Adipokine Levels in Obese Subjects with Insulin Resistance" Obesity Research 11(9): pp. 1048–1054
^Christiansen T., Richelsen B., and Bruun J.M. (2005) "Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects" International Journal of Obesity 29: pp. 146–150
The adipokines, or adipocytokines (Greek adipo-, fat; cytos-, cell; and -kinos, movement) are
cytokines (
cell signalingproteins) secreted by
adipose tissue. Some contribute to an obesity-related low-grade state of inflammation or to the development of
metabolic syndrome, a constellation of diseases including, but not limited to,
type 2 diabetes,
cardiovascular disease and
atherosclerosis.[1] The first adipokine to be discovered was
leptin in 1994.[2] Since that time, hundreds of adipokines have been discovered.[3]
^Conde J, Scotece M, Gómez R, López V, Gómez-Reino JJ, Lago F, Gualillo O (2011). "Adipokines: BioFactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity". BioFactors. 37 (6): 413–420.
doi:
10.1002/biof.185.
PMID22038756.
^Lehr S, Hartwig S, Sell H (2012). "Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders". Proteomics: Clinical Applications. 6 (1–2): 91–101.
doi:
10.1002/prca.201100052.
PMID22213627.
S2CID19427071.
^Guo L, Li Q, Wang W, Yu P, Pan H, Li P, Sun Y, Zhang J. Endocr Res. 2009; 34(4):142–154.
^MacDougald1, Ormond A. and Burant, Charles F. (September 2007) "The Rapidly Expanding Family of Adipokines" Cell Metabolism 6: pp. 159–161
^Monzillo, Lais U. (2003) "Effect of Lifestyle Modification on Adipokine Levels in Obese Subjects with Insulin Resistance" Obesity Research 11(9): pp. 1048–1054
^Christiansen T., Richelsen B., and Bruun J.M. (2005) "Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects" International Journal of Obesity 29: pp. 146–150