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Chemical and physical data | |
Formula | C22H28N2O3 |
Molar mass | 368.477 g·mol−1 |
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Pentamorphone (14β-pentylaminomorphinone, RX-77989) is a semi-synthetic opiate derivative related to compounds such as Morphinone and oxymorphone. Developed in 1984, it is a potent opioid analgesic several times stronger than fentanyl, and with a similarly fast onset of effects and short duration of action. [1] [2] It was found to produce relatively little respiratory depression compared to other potent opioid agonists, [3] but its analgesic effects were somewhat disappointing in human trials, [4] and while pentamorphone had some slight advantages over fentanyl [5] these were not sufficient to warrant its introduction into clinical use.
![]() | |
Clinical data | |
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ATC code |
|
Legal status | |
Legal status |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C22H28N2O3 |
Molar mass | 368.477 g·mol−1 |
3D model ( JSmol) | |
| |
| |
(verify) |
Pentamorphone (14β-pentylaminomorphinone, RX-77989) is a semi-synthetic opiate derivative related to compounds such as Morphinone and oxymorphone. Developed in 1984, it is a potent opioid analgesic several times stronger than fentanyl, and with a similarly fast onset of effects and short duration of action. [1] [2] It was found to produce relatively little respiratory depression compared to other potent opioid agonists, [3] but its analgesic effects were somewhat disappointing in human trials, [4] and while pentamorphone had some slight advantages over fentanyl [5] these were not sufficient to warrant its introduction into clinical use.