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Clinical data | |
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Dependence liability | High (same oxycodone) |
Identifiers | |
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CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.055.334 |
Chemical and physical data | |
Formula | C17H19NO4 |
Molar mass | 301.342 g·mol−1 |
3D model ( JSmol) | |
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Noroxycodone is the major metabolite of the opioid analgesic oxycodone. [1] [2] [3] It is formed from oxycodone in the liver via N- demethylation predominantly by CYP3A4. [1] [2] [3] Noroxycodone binds to and activates the μ-opioid receptor (MOR) similarly to oxycodone, although with one-third of the affinity of oxycodone and 5- to 10-fold lower activational potency. [1] [4] [5] However, although a potent MOR agonist, noroxycodone poorly crosses the blood-brain-barrier into the central nervous system, and for this reason, is only minimally analgesic in comparison. [6] [5] [4] [7]
![]() | |
Clinical data | |
---|---|
Dependence liability | High (same oxycodone) |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.055.334 |
Chemical and physical data | |
Formula | C17H19NO4 |
Molar mass | 301.342 g·mol−1 |
3D model ( JSmol) | |
| |
|
Noroxycodone is the major metabolite of the opioid analgesic oxycodone. [1] [2] [3] It is formed from oxycodone in the liver via N- demethylation predominantly by CYP3A4. [1] [2] [3] Noroxycodone binds to and activates the μ-opioid receptor (MOR) similarly to oxycodone, although with one-third of the affinity of oxycodone and 5- to 10-fold lower activational potency. [1] [4] [5] However, although a potent MOR agonist, noroxycodone poorly crosses the blood-brain-barrier into the central nervous system, and for this reason, is only minimally analgesic in comparison. [6] [5] [4] [7]