SN-22 is a chemical compound which acts as a moderately
selectiveagonist at the
5-HT2 family of
serotoninreceptors, with a Ki of 19 nM at 5-HT2 subtypes versus 514 nM at 5-HT1A receptors.[1] Many related derivatives are known, most of which are ligands for 5-HT1A, 5-HT6 or dopamine D2 receptors or show
SSRI activity.[2][3][4][5][6]
^Taylor EW, Nikam SS, Lambert G, Martin AR, Nelson DL (July 1988). "Molecular determinants for recognition of RU 24969 analogs at central 5-hydroxytryptamine recognition sites: use of a bilinear function and substituent volumes to describe steric fit". Molecular Pharmacology. 34 (1): 42–53.
PMID3393140.
^Agarwal A, Pearson PP, Taylor EW, Li HB, Dahlgren T, Herslöf M, et al. (December 1993). "Three-dimensional quantitative structure-activity relationships of 5-HT receptor binding data for tetrahydropyridinylindole derivatives: a comparison of the Hansch and CoMFA methods". Journal of Medicinal Chemistry. 36 (25): 4006–14.
doi:
10.1021/jm00077a003.
PMID8258822.
^Cole DC, Ellingboe JW, Lennox WJ, Mazandarani H, Smith DL, Stock JR, et al. (January 2005). "N1-arylsulfonyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives are potent and selective 5-HT6 receptor antagonists". Bioorganic & Medicinal Chemistry Letters. 15 (2): 379–83.
doi:
10.1016/j.bmcl.2004.10.064.
PMID15603958.
^Mattsson C, Andreasson T, Waters N, Sonesson C (November 2012). "Systematic in vivo screening of a series of 1-propyl-4-arylpiperidines against dopaminergic and serotonergic properties in rat brain: a scaffold-jumping approach". Journal of Medicinal Chemistry. 55 (22): 9735–50.
doi:
10.1021/jm300975f.
PMID23043306.
SN-22 is a chemical compound which acts as a moderately
selectiveagonist at the
5-HT2 family of
serotoninreceptors, with a Ki of 19 nM at 5-HT2 subtypes versus 514 nM at 5-HT1A receptors.[1] Many related derivatives are known, most of which are ligands for 5-HT1A, 5-HT6 or dopamine D2 receptors or show
SSRI activity.[2][3][4][5][6]
^Taylor EW, Nikam SS, Lambert G, Martin AR, Nelson DL (July 1988). "Molecular determinants for recognition of RU 24969 analogs at central 5-hydroxytryptamine recognition sites: use of a bilinear function and substituent volumes to describe steric fit". Molecular Pharmacology. 34 (1): 42–53.
PMID3393140.
^Agarwal A, Pearson PP, Taylor EW, Li HB, Dahlgren T, Herslöf M, et al. (December 1993). "Three-dimensional quantitative structure-activity relationships of 5-HT receptor binding data for tetrahydropyridinylindole derivatives: a comparison of the Hansch and CoMFA methods". Journal of Medicinal Chemistry. 36 (25): 4006–14.
doi:
10.1021/jm00077a003.
PMID8258822.
^Cole DC, Ellingboe JW, Lennox WJ, Mazandarani H, Smith DL, Stock JR, et al. (January 2005). "N1-arylsulfonyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives are potent and selective 5-HT6 receptor antagonists". Bioorganic & Medicinal Chemistry Letters. 15 (2): 379–83.
doi:
10.1016/j.bmcl.2004.10.064.
PMID15603958.
^Mattsson C, Andreasson T, Waters N, Sonesson C (November 2012). "Systematic in vivo screening of a series of 1-propyl-4-arylpiperidines against dopaminergic and serotonergic properties in rat brain: a scaffold-jumping approach". Journal of Medicinal Chemistry. 55 (22): 9735–50.
doi:
10.1021/jm300975f.
PMID23043306.