EPH receptor A2 (ephrin type-A receptor 2) is a
protein that in humans is encoded by the EPHA2gene.[5][6]
Function
This gene belongs to the
ephrin receptor subfamily of the
protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the
nervous system. Receptors in the EPH subfamily typically have a single
kinase domain and an extracellular region containing a
Cys-rich domain and 2
fibronectin type III repeats. The ephrin receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding
ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands.[6]
Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–44.
doi:
10.1242/dev.126.10.2033.
PMID10207129.
Pandey A, Shao H, Marks RM, Polverini PJ, Dixit VM (1995). "Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis". Science. 268 (5210): 567–9.
Bibcode:
1995Sci...268..567P.
doi:
10.1126/science.7536959.
PMID7536959.
Ruiz JC, Robertson EJ (1994). "The expression of the receptor-protein tyrosine kinase gene, eck, is highly restricted during early mouse development". Mech. Dev. 46 (2): 87–100.
doi:
10.1016/0925-4773(94)90078-7.
PMID7918100.
S2CID21419336.
Davis S, Gale NW, Aldrich TH, Maisonpierre PC, Lhotak V, Pawson T, Goldfarb M, Yancopoulos GD (1994). "Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity". Science. 266 (5186): 816–9.
Bibcode:
1994Sci...266..816D.
doi:
10.1126/science.7973638.
PMID7973638.
Ganju P, Shigemoto K, Brennan J, Entwistle A, Reith AD (1994). "The Eck receptor tyrosine kinase is implicated in pattern formation during gastrulation, hindbrain segmentation and limb development". Oncogene. 9 (6): 1613–24.
PMID8183555.
Kozlosky CJ, VandenBos T, Park L, Cerretti DP, Carpenter MK (1997). "LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain". Cytokine. 9 (8): 540–9.
doi:
10.1006/cyto.1997.0199.
PMID9245480.
EPH receptor A2 (ephrin type-A receptor 2) is a
protein that in humans is encoded by the EPHA2gene.[5][6]
Function
This gene belongs to the
ephrin receptor subfamily of the
protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the
nervous system. Receptors in the EPH subfamily typically have a single
kinase domain and an extracellular region containing a
Cys-rich domain and 2
fibronectin type III repeats. The ephrin receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding
ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands.[6]
Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–44.
doi:
10.1242/dev.126.10.2033.
PMID10207129.
Pandey A, Shao H, Marks RM, Polverini PJ, Dixit VM (1995). "Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis". Science. 268 (5210): 567–9.
Bibcode:
1995Sci...268..567P.
doi:
10.1126/science.7536959.
PMID7536959.
Ruiz JC, Robertson EJ (1994). "The expression of the receptor-protein tyrosine kinase gene, eck, is highly restricted during early mouse development". Mech. Dev. 46 (2): 87–100.
doi:
10.1016/0925-4773(94)90078-7.
PMID7918100.
S2CID21419336.
Davis S, Gale NW, Aldrich TH, Maisonpierre PC, Lhotak V, Pawson T, Goldfarb M, Yancopoulos GD (1994). "Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity". Science. 266 (5186): 816–9.
Bibcode:
1994Sci...266..816D.
doi:
10.1126/science.7973638.
PMID7973638.
Ganju P, Shigemoto K, Brennan J, Entwistle A, Reith AD (1994). "The Eck receptor tyrosine kinase is implicated in pattern formation during gastrulation, hindbrain segmentation and limb development". Oncogene. 9 (6): 1613–24.
PMID8183555.
Kozlosky CJ, VandenBos T, Park L, Cerretti DP, Carpenter MK (1997). "LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain". Cytokine. 9 (8): 540–9.
doi:
10.1006/cyto.1997.0199.
PMID9245480.