EPH receptor A1 (ephrin type-A receptor 1) is a
protein that in humans is encoded by the EPHA1gene.[5][6]
This gene belongs to the
ephrin receptor subfamily of the
protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the
nervous system. Receptors in the EPH subfamily typically have a single
kinase domain and an extracellular region containing a Cys-rich domain and 2
fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B
ligands. This gene is expressed in some human
cancer cell lines and has been implicated in
carcinogenesis.[6]
Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–44.
doi:
10.1242/dev.126.10.2033.
PMID10207129.
EPH receptor A1 (ephrin type-A receptor 1) is a
protein that in humans is encoded by the EPHA1gene.[5][6]
This gene belongs to the
ephrin receptor subfamily of the
protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the
nervous system. Receptors in the EPH subfamily typically have a single
kinase domain and an extracellular region containing a Cys-rich domain and 2
fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B
ligands. This gene is expressed in some human
cancer cell lines and has been implicated in
carcinogenesis.[6]
Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–44.
doi:
10.1242/dev.126.10.2033.
PMID10207129.