From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Ephrin type-A receptor 6 is a
protein that in humans is encoded by the EPHA6
gene .
[5]
[6]
EphA6 may serve an important role in breast
carcinogenesis and may pose as a novel prognostic indicator and therapeutic target for
breast cancer , particularly in patients with
steroid receptor negative expression and HER‑2 overexpression
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000080224 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000055540 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (December 2002). "The protein kinase complement of the human genome". Science . 298 (5600): 1912–34.
Bibcode :
2002Sci...298.1912M .
doi :
10.1126/science.1075762 .
PMID
12471243 .
S2CID
26554314 .
^
"Entrez Gene: EPHA6 EPH receptor A6" .
^ Zhou D, Ren K, Wang J, Ren H, Yang W, Wang W, et al. (April 2018).
"Erythropoietin-producing hepatocellular A6 overexpression is a novel biomarker of poor prognosis in patients with breast cancer" . Oncology Letters . 15 (4): 5257–5263.
doi :
10.3892/ol.2018.7919 .
PMC
5840743 .
PMID
29552165 .
Further reading
Wilkinson DG (2000). Eph receptors and ephrins: regulators of guidance and assembly . International Review of Cytology. Vol. 196. pp. 177–244.
doi :
10.1016/S0074-7696(00)96005-4 .
ISBN
978-0-12-364600-2 .
PMID
10730216 .
Xu Q, Mellitzer G, Wilkinson DG (July 2000).
"Roles of Eph receptors and ephrins in segmental patterning" . Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences . 355 (1399): 993–1002.
doi :
10.1098/rstb.2000.0635 .
PMC
1692797 .
PMID
11128993 .
Nakamoto T, Kain KH, Ginsberg MH (February 2004).
"Neurobiology: New connections between integrins and axon guidance" . Current Biology . 14 (3): R121-3.
Bibcode :
2004CBio...14.R121N .
doi :
10.1016/j.cub.2004.01.020 .
PMID
14986683 .
S2CID
2957639 .
Yamaguchi Y, Pasquale EB (June 2004). "Eph receptors in the adult brain". Current Opinion in Neurobiology . 14 (3): 288–96.
doi :
10.1016/j.conb.2004.04.003 .
PMID
15194108 .
S2CID
26196696 .
Murai KK, Pasquale EB (August 2004). "Eph receptors, ephrins, and synaptic function". The Neuroscientist . 10 (4): 304–14.
doi :
10.1177/1073858403262221 .
PMID
15271258 .
S2CID
23900846 .
Gale NW, Holland SJ, Valenzuela DM, Flenniken A, Pan L, Ryan TE, et al. (July 1996).
"Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis" . Neuron . 17 (1): 9–19.
doi :
10.1016/S0896-6273(00)80276-7 .
PMID
8755474 .
S2CID
1075856 .
Aasheim HC, Munthe E, Funderud S, Smeland EB, Beiske K, Logtenberg T (January 2000). "A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes". Blood . 95 (1): 221–30.
doi :
10.1182/blood.V95.1.221 .
PMID
10607706 .
Prevost N, Woulfe D, Tanaka T, Brass LF (July 2002).
"Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred" . Proceedings of the National Academy of Sciences of the United States of America . 99 (14): 9219–24.
Bibcode :
2002PNAS...99.9219P .
doi :
10.1073/pnas.142053899 .
PMC
123121 .
PMID
12084815 .
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (October 2003).
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment" . Genome Research . 13 (10): 2265–70.
doi :
10.1101/gr.1293003 .
PMC
403697 .
PMID
12975309 .
Hafner C, Schmitz G, Meyer S, Bataille F, Hau P, Langmann T, et al. (March 2004).
"Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers" . Clinical Chemistry . 50 (3): 490–9.
doi :
10.1373/clinchem.2003.026849 .
PMID
14726470 .
External links
Overview of all the structural information available in the
PDB for
UniProt :
Q62413 (Mouse Ephrin type-A receptor 6) at the
PDBe-KB .
Activity Regulation Classification Kinetics Types
Angiopoietin
CNTF
EGF (ErbB)
FGF
FGFR1
FGFR2
Agonists:
Ersofermin
FGF (
1 ,
2 (bFGF) ,
3 ,
4 ,
5 ,
6 ,
7 (
KGF ),
8 ,
9 ,
10 (KGF2) ,
17 ,
18 ,
22 )
Palifermin
Repifermin
Selpercatinib
Sprifermin
Trafermin
FGFR3
FGFR4 Unsorted
HGF (c-Met)
IGF
LNGF (p75NTR )
PDGF
RET (GFL)
SCF (c-Kit)
TGFβ
Trk
TrkA
Negative allosteric modulators:
VM-902A
TrkB
Agonists:
3,7-DHF
3,7,8,2'-THF
4'-DMA-7,8-DHF
7,3'-DHF
7,8-DHF
7,8,2'-THF
7,8,3'-THF
Amitriptyline
BDNF
BNN-20
Deoxygedunin
Deprenyl
Diosmetin
DMAQ-B1
HIOC
LM22A-4
N-Acetylserotonin
NT-3
NT-4
Norwogonin (5,7,8-THF)
R7
R13
TDP6
TrkC
VEGF Others
Additional growth factors:
Adrenomedullin
Colony-stimulating factors (see
here instead)
Connective tissue growth factor (CTGF)
Ephrins (
A1 ,
A2 ,
A3 ,
A4 ,
A5 ,
B1 ,
B2 ,
B3 )
Erythropoietin (see
here instead)
Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
Glia maturation factor (GMF)
Hepatoma-derived growth factor (HDGF)
Interleukins /
T-cell growth factors (see
here instead)
Leukemia inhibitory factor (LIF)
Macrophage-stimulating protein (MSP; HLP, HGFLP)
Midkine (NEGF2)
Migration-stimulating factor (MSF; PRG4)
Oncomodulin
Pituitary adenylate cyclase-activating peptide (PACAP)
Pleiotrophin
Renalase
Thrombopoietin (see
here instead)
Wnt signaling proteins
Additional growth factor receptor modulators:
Cerebrolysin (neurotrophin mixture)