This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats.[8] The ligand for the receptor is angiopoietin-1.[7] TEK has also been suggested as a marker for
nucleus pulposus progenitor cells, from the
intervertebral disc, which upon activation by
Angiopoietin-1 starts to multiply and differentiate.[9][10]
Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis.[7]
In cancer patients, TEK (Tie2) is expressed in a subpopulation of monocytes that home in on the tumor and are essential for the formation of new blood vessels there.[11]
Interactions
TEK tyrosine kinase has been shown to
interact with:
^Boon LM, Mulliken JB, Vikkula M, Watkins H, Seidman J, Olsen BR, Warman ML (September 1994). "Assignment of a locus for dominantly inherited venous malformations to chromosome 9p". Human Molecular Genetics. 3 (9): 1583–7.
doi:
10.1093/hmg/3.9.1583.
PMID7833915.
^
abMaisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD (July 1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science. 277 (5322): 55–60.
doi:
10.1126/science.277.5322.55.
PMID9204896.
^Jones N, Dumont DJ (September 1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R". Oncogene. 17 (9): 1097–108.
doi:
10.1038/sj.onc.1202115.
PMID9764820.
S2CID20187169.
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (September 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50.
doi:
10.1006/geno.1994.1457.
PMID7829101.
Dumont DJ, Anderson L, Breitman ML, Duncan AM (September 1994). "Assignment of the endothelial-specific protein receptor tyrosine kinase gene (TEK) to human chromosome 9p21". Genomics. 23 (2): 512–3.
doi:
10.1006/geno.1994.1536.
PMID7835909.
Ziegler SF, Bird TA, Schneringer JA, Schooley KA, Baum PR (March 1993). "Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta". Oncogene. 8 (3): 663–70.
PMID8382358.
Jones N, Dumont DJ (September 1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R". Oncogene. 17 (9): 1097–108.
doi:
10.1038/sj.onc.1202115.
PMID9764820.
S2CID20187169.
This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats.[8] The ligand for the receptor is angiopoietin-1.[7] TEK has also been suggested as a marker for
nucleus pulposus progenitor cells, from the
intervertebral disc, which upon activation by
Angiopoietin-1 starts to multiply and differentiate.[9][10]
Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis.[7]
In cancer patients, TEK (Tie2) is expressed in a subpopulation of monocytes that home in on the tumor and are essential for the formation of new blood vessels there.[11]
Interactions
TEK tyrosine kinase has been shown to
interact with:
^Boon LM, Mulliken JB, Vikkula M, Watkins H, Seidman J, Olsen BR, Warman ML (September 1994). "Assignment of a locus for dominantly inherited venous malformations to chromosome 9p". Human Molecular Genetics. 3 (9): 1583–7.
doi:
10.1093/hmg/3.9.1583.
PMID7833915.
^
abMaisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD (July 1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science. 277 (5322): 55–60.
doi:
10.1126/science.277.5322.55.
PMID9204896.
^Jones N, Dumont DJ (September 1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R". Oncogene. 17 (9): 1097–108.
doi:
10.1038/sj.onc.1202115.
PMID9764820.
S2CID20187169.
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (September 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50.
doi:
10.1006/geno.1994.1457.
PMID7829101.
Dumont DJ, Anderson L, Breitman ML, Duncan AM (September 1994). "Assignment of the endothelial-specific protein receptor tyrosine kinase gene (TEK) to human chromosome 9p21". Genomics. 23 (2): 512–3.
doi:
10.1006/geno.1994.1536.
PMID7835909.
Ziegler SF, Bird TA, Schneringer JA, Schooley KA, Baum PR (March 1993). "Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta". Oncogene. 8 (3): 663–70.
PMID8382358.
Jones N, Dumont DJ (September 1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R". Oncogene. 17 (9): 1097–108.
doi:
10.1038/sj.onc.1202115.
PMID9764820.
S2CID20187169.