From Wikipedia, the free encyclopedia
SEMA4D
Identifiers
Aliases
SEMA4D , C9orf164, CD100, M-sema-G, SEMAJ, coll-4, semaphorin 4D, COLL4, A8, GR3, BB18External IDs
OMIM :
601866 ;
MGI :
109244 ;
HomoloGene :
21282 ;
GeneCards :
SEMA4D ;
OMA :
SEMA4D - orthologs
Wikidata
Semaphorin-4D (SEMA4D ) also known as C luster of D ifferentiation 100 (CD100 ), is a
protein of the
semaphorin family that in humans is encoded by the SEMA4D
gene .
[5]
Function
Semaphorin 4D (Sema 4D) is an
axon guidance molecule which is secreted by
oligodendrocytes and induces
growth cone collapse in the
central nervous system . By binding
plexin B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature central nervous system.
[6]
In the immune system, CD100 binds
CD72 to activate
B cells and
dendritic cells , though much about this interaction is still under investigation.
[7]
[8]
During
skin damage repairs, SEMA4D interacts with
Plexin B2 on
Gamma delta T cells to play a role in the healing process.
[9]
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000187764 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000021451 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Entrez Gene: SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D" .
^ Ito Y, Oinuma I, Katoh H, Kaibuchi K, Negishi M (July 2006).
"Sema4D/plexin-B1 activates GSK-3β through R-Ras GAP activity, inducing growth cone collapse" . EMBO Reports . 7 (7): 704–9.
doi :
10.1038/sj.embor.7400737 .
PMC
1500830 .
PMID
16799460 .
^ Kumanogoh A, Watanabe C, Lee I, Wang X, Shi W, Araki H, Hirata H, Iwahori K, Uchida J, Yasui T, Matsumoto M, Yoshida K, Yakura H, Pan C, Parnes JR, Kikutani H (November 2000).
"Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling" . Immunity . 13 (5): 621–31.
doi :
10.1016/S1074-7613(00)00062-5 .
PMID
11114375 .
^ Ishida I, Kumanogoh A, Suzuki K, Akahani S, Noda K, Kikutani H (August 2003).
"Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses" . Int. Immunol . 15 (8): 1027–34.
doi :
10.1093/intimm/dxg098 .
PMID
12882840 .
^ Deborah A. Witherden, Megumi Watanabe, Olivia Garijo, Stephanie E. Rieder, Gor Sarkisyan, Shane J.F. Cronin, Petra Verdino, Ian A. Wilson, Atsushi Kumanogoh, Hitoshi Kikutani, Luc Teyton, Wolfgang H. Fischer, Wendy L. Havran (August 2012).
"The CD100 Receptor Interacts with Its Plexin B2 Ligand to Regulate Epidermal γδ T Cell Function" . Immunity . 37 (2): 314–25.
doi :
10.1016/j.immuni.2012.05.026 .
PMC
3430606 .
PMID
22902232 .
Further reading
Bougeret C, Mansur IG, Dastot H, et al. (1992).
"Increased surface expression of a newly identified 150-kDa dimer early after human T lymphocyte activation" . J. Immunol . 148 (2): 318–23.
doi :
10.4049/jimmunol.148.2.318 .
PMID
1530858 .
S2CID
29224711 .
Hall KT, Boumsell L, Schultze JL, et al. (1996).
"Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation" . Proc. Natl. Acad. Sci. U.S.A . 93 (21): 11780–5.
Bibcode :
1996PNAS...9311780H .
doi :
10.1073/pnas.93.21.11780 .
PMC
38135 .
PMID
8876214 .
Herold C, Elhabazi A, Bismuth G, et al. (1997).
"CD100 is associated with CD45 at the surface of human T lymphocytes. Role in T cell homotypic adhesion" . J. Immunol . 157 (12): 5262–8.
doi :
10.4049/jimmunol.157.12.5262 .
PMID
8955171 .
S2CID
36341775 .
Furuyama T, Inagaki S, Kosugi A, et al. (1997).
"Identification of a novel transmembrane semaphorin expressed on lymphocytes" . J. Biol. Chem . 271 (52): 33376–81.
doi :
10.1074/jbc.271.52.33376 .
PMID
8969198 .
Tamagnone L, Artigiani S, Chen H, et al. (1999).
"Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates" . Cell . 99 (1): 71–80.
doi :
10.1016/S0092-8674(00)80063-X .
PMID
10520995 .
S2CID
17386412 .
Elhabazi A, Delaire S, Bensussan A, et al. (2001).
"Biological activity of soluble CD100. I. The extracellular region of CD100 is released from the surface of T lymphocytes by regulated proteolysis" . J. Immunol . 166 (7): 4341–7.
doi :
10.4049/jimmunol.166.7.4341 .
PMID
11254687 .
Delaire S, Billard C, Tordjman R, et al. (2001).
"Biological activity of soluble CD100. II. Soluble CD100, similarly to H-SemaIII, inhibits immune cell migration" . J. Immunol . 166 (7): 4348–54.
doi :
10.4049/jimmunol.166.7.4348 .
PMID
11254688 .
Vikis HG, Li W, Guan KL (2002).
"The Plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding" . Genes Dev . 16 (7): 836–45.
doi :
10.1101/gad.966402 .
PMC
186329 .
PMID
11937491 .
Granziero L, Circosta P, Scielzo C, et al. (2003).
"CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes" . Blood . 101 (5): 1962–9.
doi :
10.1182/blood-2002-05-1339 .
PMID
12406905 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med . 9 (2): 191–7.
doi :
10.1038/nm822 .
PMID
12539042 .
S2CID
26145639 .
Love CA, Harlos K, Mavaddat N, et al. (2003). "The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D". Nat. Struct. Biol . 10 (10): 843–8.
doi :
10.1038/nsb977 .
PMID
12958590 .
S2CID
24468463 .
Giraudon P, Vincent P, Vuaillat C, et al. (2004).
"Semaphorin CD100 from activated T lymphocytes induces process extension collapse in oligodendrocytes and death of immature neural cells" . J. Immunol . 172 (2): 1246–55.
doi :
10.4049/jimmunol.172.2.1246 .
PMID
14707103 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Deaglio S, Vaisitti T, Bergui L, et al. (2005).
"CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival" . Blood . 105 (8): 3042–50.
doi :
10.1182/blood-2004-10-3873 .
PMID
15613544 .
Conrotto P, Valdembri D, Corso S, et al. (2005).
"Sema4D induces angiogenesis through Met recruitment by Plexin B1" . Blood . 105 (11): 4321–9.
doi :
10.1182/blood-2004-07-2885 .
PMID
15632204 .
Basile JR, Afkhami T, Gutkind JS (2005).
"Semaphorin 4D/Plexin-B1 Induces Endothelial Cell Migration through the Activation of PYK2, Src, and the Phosphatidylinositol 3-Kinase-Akt Pathway" . Mol. Cell. Biol . 25 (16): 6889–98.
doi :
10.1128/MCB.25.16.6889-6898.2005 .
PMC
1190270 .
PMID
16055703 .
Lewandrowski U, Moebius J, Walter U, Sickmann A (2006).
"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach" . Mol. Cell. Proteomics . 5 (2): 226–33.
doi :
10.1074/mcp.M500324-MCP200 .
PMID
16263699 .
Nkyimbeng-Takwi EH, Chapoval SP (2011).
"Biology and function of neuroimmune semaphorins 4A and 4D" . Immunol. Res . 50 (1): 10–21.
doi :
10.1007/s12026-010-8201-y .
PMC
3366695 .
PMID
21203905 .
Smith EP, Shanks K, Lipsky MM, DeTolla LJ, Keegan AD, Chapoval SP (2011).
"Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor" . BMC Immunol . 12 : 30.
doi :
10.1186/1471-2172-12-30 .
PMC
3118960 .
PMID
21595947 .
Shanks K, Nkyimbeng-Takwi EH, Smith EP, Lipsky MM, DeTolla LJ, Keegan AD, Chapoval SP (2013).
"Neuroimmune semaphorin 4D is necessary for optimal lung allergic inflammation" . Mol. Immunol . 56 (4): 480–7.
doi :
10.1016/j.molimm.2013.05.228 .
PMC
3783523 .
PMID
23911404 .
External links
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