From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Plexin B1 is a
protein of the
plexin family that in humans is encoded by the PLXNB1
gene .
[5]
[6]
[7]
Function
Within neural tissues, the
plexin family serves as transmembrane receptors for
Semaphorins .
[8] Outside of neural tissues, Plexin B1 is implicated in the control of cell migration.
[9]
Interactions
PLXNB1 has been shown to
interact with
ARHGEF12 ,
[10]
Rnd1
[11] and
ARHGEF11 .
[10]
[11]
[12]
[13]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000164050 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000053646 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM (Mar 1996).
"A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor" . Proc Natl Acad Sci U S A . 93 (2): 674–8.
Bibcode :
1996PNAS...93..674M .
doi :
10.1073/pnas.93.2.674 .
PMC
40111 .
PMID
8570614 .
^ Vikis HG, Li W, He Z, Guan KL (Nov 2000).
"The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner" . Proc Natl Acad Sci U S A . 97 (23): 12457–62.
Bibcode :
2000PNAS...9712457V .
doi :
10.1073/pnas.220421797 .
PMC
18785 .
PMID
11035813 .
^
"Entrez Gene: PLXNB1 plexin B1" .
^ Driessens MH, Olivo C, Nagata K, Inagaki M, Collard JG (Oct 9, 2002).
"B plexins activate Rho through PDZ-RhoGEF" . FEBS Letters . 529 (2–3): 168–72.
doi :
10.1016/s0014-5793(02)03323-9 .
PMID
12372594 .
S2CID
26525009 .
^ Basile JR, Afkhami T, Gutkind JS (Aug 2005).
"Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway" . Molecular and Cellular Biology . 25 (16): 6889–98.
doi :
10.1128/mcb.25.16.6889-6898.2005 .
PMC
1190270 .
PMID
16055703 .
^
a
b Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S (Sep 2002). "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun . 297 (1): 32–7.
doi :
10.1016/S0006-291X(02)02122-8 .
PMID
12220504 .
^
a
b Oinuma I, Katoh H, Harada A, Negishi M (Jul 2003).
"Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells" . J. Biol. Chem . 278 (28): 25671–7.
doi :
10.1074/jbc.M303047200 .
PMID
12730235 .
^ Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002).
"Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF" . J. Biol. Chem . 277 (45): 43115–20.
doi :
10.1074/jbc.M206005200 .
PMID
12183458 .
^ Swiercz JM, Kuner R, Behrens J, Offermanns S (Jul 2002).
"Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology" . Neuron . 35 (1): 51–63.
doi :
10.1016/S0896-6273(02)00750-X .
PMID
12123608 .
S2CID
18981429 .
Chapoval SP, Hritzo M, Qi X, Tamagnone L, Golding A and Keegan AD. "Semaphorin 4A Stabilizes Human Regulatory T Cell Phenotype via Plexin B1". ImmunoHorizons, February 1, 2019, 3 (2) 71-87;
doi :
10.4049/immunohorizons.1800026
Further reading
Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998).
"Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 4 (5): 307–13.
doi :
10.1093/dnares/4.5.307 .
PMID
9455477 .
Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM (1999).
"Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates" . Cell . 99 (1): 71–80.
doi :
10.1016/S0092-8674(00)80063-X .
PMID
10520995 .
S2CID
17386412 .
Vikis HG, Li W, Guan KL (2002).
"The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding" . Genes Dev . 16 (7): 836–45.
doi :
10.1101/gad.966402 .
PMC
186329 .
PMID
11937491 .
Swiercz JM, Kuner R, Behrens J, Offermanns S (2002).
"Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology" . Neuron . 35 (1): 51–63.
doi :
10.1016/S0896-6273(02)00750-X .
PMID
12123608 .
S2CID
18981429 .
Perrot V, Vazquez-Prado J, Gutkind JS (2003).
"Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF" . J. Biol. Chem . 277 (45): 43115–20.
doi :
10.1074/jbc.M206005200 .
PMID
12183458 .
Aurandt J, Vikis HG, Gutkind JS, Ahn N, Guan KL (2002).
"The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG" . Proc. Natl. Acad. Sci. U.S.A . 99 (19): 12085–90.
Bibcode :
2002PNAS...9912085A .
doi :
10.1073/pnas.142433199 .
PMC
129402 .
PMID
12196628 .
Giordano S, Corso S, Conrotto P, Artigiani S, Gilestro G, Barberis D, Tamagnone L, Comoglio PM (2002). "The semaphorin 4D receptor controls invasive growth by coupling with Met". Nat. Cell Biol . 4 (9): 720–4.
doi :
10.1038/ncb843 .
PMID
12198496 .
S2CID
130071 .
Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S (2002). "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun . 297 (1): 32–7.
doi :
10.1016/S0006-291X(02)02122-8 .
PMID
12220504 .
Granziero L, Circosta P, Scielzo C, Frisaldi E, Stella S, Geuna M, Giordano S, Ghia P, Caligaris-Cappio F (2003).
"CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes" . Blood . 101 (5): 1962–9.
doi :
10.1182/blood-2002-05-1339 .
PMID
12406905 .
Artigiani S, Barberis D, Fazzari P, Longati P, Angelini P, van de Loo JW, Comoglio PM, Tamagnone L (2003).
"Functional regulation of semaphorin receptors by proprotein convertases" . J. Biol. Chem . 278 (12): 10094–101.
doi :
10.1074/jbc.M210156200 .
PMID
12533544 .
Usui H, Taniguchi M, Yokomizo T, Shimizu T (2003). "Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains". Biochem. Biophys. Res. Commun . 300 (4): 927–31.
doi :
10.1016/S0006-291X(02)02966-2 .
PMID
12559962 .
Oinuma I, Katoh H, Harada A, Negishi M (2003).
"Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells" . J. Biol. Chem . 278 (28): 25671–7.
doi :
10.1074/jbc.M303047200 .
PMID
12730235 .
Conrotto P, Corso S, Gamberini S, Comoglio PM, Giordano S (2004). "Interplay between scatter factor receptors and B plexins controls invasive growth". Oncogene . 23 (30): 5131–7.
doi :
10.1038/sj.onc.1207650 .
PMID
15184888 .
S2CID
24596233 .
Swiercz JM, Kuner R, Offermanns S (2004).
"Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2" . J. Cell Biol . 165 (6): 869–80.
doi :
10.1083/jcb.200312094 .
PMC
2172401 .
PMID
15210733 .
Oinuma I, Ishikawa Y, Katoh H, Negishi M (2004). "The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras". Science . 305 (5685): 862–5.
Bibcode :
2004Sci...305..862O .
doi :
10.1126/science.1097545 .
PMID
15297673 .
S2CID
39544623 .
Conrotto P, Valdembri D, Corso S, Serini G, Tamagnone L, Comoglio PM, Bussolino F, Giordano S (2005).
"Sema4D induces angiogenesis through Met recruitment by Plexin B1" . Blood . 105 (11): 4321–9.
doi :
10.1182/blood-2004-07-2885 .
PMID
15632204 .
External links