Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.
The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene. [5] Specific loss of this integrin chain in the intestinal epithelium, and thus of their hemidesmosomes, induces long-standing colitis and infiltrating adenocarcinomas. [6]
ITGA6 has been shown to interact with TSPAN4 [7] and GIPC1. [8]
ITGA6 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | ITGA6, CD49f, ITGA6B, VLA-6, integrin subunit alpha 6, JEB6 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 147556; MGI: 96605; HomoloGene: 20091; GeneCards: ITGA6; OMA: ITGA6 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.
The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene. [5] Specific loss of this integrin chain in the intestinal epithelium, and thus of their hemidesmosomes, induces long-standing colitis and infiltrating adenocarcinomas. [6]
ITGA6 has been shown to interact with TSPAN4 [7] and GIPC1. [8]