Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene. [5]
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [6]
ITGA5 has been shown to interact with GIPC1. [7]
ITGA5 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | ITGA5, CD49e, FNRA, VLA5A, VLA-5, integrin subunit alpha 5 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 135620; MGI: 96604; HomoloGene: 20508; GeneCards: ITGA5; OMA: ITGA5 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene. [5]
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [6]
ITGA5 has been shown to interact with GIPC1. [7]