Sodium/potassium-transporting ATPase subunit beta-3 is an enzyme that in humans is encoded by the ATP1B3 gene. [5] [6] [7] ATP1B3 has also been designated as CD298 ( cluster of differentiation 298).
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium- coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [7]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
ATP1B3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | ATP1B3, ATPB-3, CD298, ATPase Na+/K+ transporting subunit beta 3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 601867; MGI: 107788; HomoloGene: 37510; GeneCards: ATP1B3; OMA: ATP1B3 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Sodium/potassium-transporting ATPase subunit beta-3 is an enzyme that in humans is encoded by the ATP1B3 gene. [5] [6] [7] ATP1B3 has also been designated as CD298 ( cluster of differentiation 298).
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium- coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [7]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.