From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Guanine nucleotide-binding protein subunit alpha-12 is a
protein that in humans is encoded by the GNA12
gene .
[5]
[6]
[7]
Interactions and functions
The GNA12 gene encodes the G12
G protein alpha subunit . Together with
GNA13 , these two proteins comprise one of the four classes of
heterotrimeric G protein alpha subunits.
[8] Heterotrimeric G proteins function in transducing
hormone and
neurotransmitter signals detected by cell surface
G protein-coupled receptors to
intracellular signaling pathways to modulate cell functions. G protein alpha subunits bind to guanine nucleotides and function in a regulatory cycle, and are active when bound to
GTP but inactive and associated with the
G beta-gamma complex when bound to
GDP .
[9]
[10]
Active GTP-bound G12 alpha subunit
interacts with and activates
ARHGEF1 ,
[11]
ARHGEF11 ,
[12]
[13] and
ARHGEF12 .
[14]
[15] These ARHGEF proteins function as
guanine nucleotide exchange factors for the
Rho
small GTPases to regulate the
actin
cytoskeleton .
[16]
GNA12 also interacts with
PPP5C ,
[17]
HSP90 ,
[18]
Resistance to inhibitors of cholinesterase-8A (Ric-8A)
[19] and
TEC .
[15]
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000146535 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000000149 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA (February 1993).
"Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product" . Molecular and Cellular Biology . 13 (2): 762–8.
doi :
10.1128/mcb.13.2.762 .
PMC
358958 .
PMID
8423800 .
^ Kumar RN, Shore SK, Dhanasekaran N (February 2006).
"Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3" . Oncogene . 25 (6): 899–906.
doi :
10.1038/sj.onc.1209132 .
PMID
16247467 .
^
"Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12" .
^ Strathmann MP, Simon MI (1991).
"G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits" . Proc. Natl. Acad. Sci. U.S.A . 88 (13): 5582–6.
Bibcode :
1991PNAS...88.5582S .
doi :
10.1073/pnas.88.13.5582 .
PMC
51921 .
PMID
1905812 .
^ Gilman, AG (1987). "G proteins: transducers of receptor-generated signals". Annual Review of Biochemistry . 56 : 615–649.
doi :
10.1146/annurev.bi.56.070187.003151 .
PMID
3113327 .
^ Rodbell, M (1995).
"Nobel Lecture: Signal transduction: Evolution of an idea" . Bioscience Reports . 15 (3): 117–133.
doi :
10.1007/bf01207453 .
PMC
1519115 .
PMID
7579038 .
S2CID
11025853 .
^ Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM (December 2003).
"RGS16 inhibits signalling through the G alpha 13-Rho axis" . Nature Cell Biology . 5 (12): 1095–103.
doi :
10.1038/ncb1065 .
PMID
14634662 .
S2CID
6798899 .
^ Fukuhara, S; Murga, C; Zohar, M; Igishi, T; Gutkind, JS (1999-02-26).
"A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho" . Journal of Biological Chemistry . 274 (9): 5868–5879.
doi :
10.1074/jbc.274.9.5868 .
PMID
10026210 .
^ Rümenapp, U; Blomquist, A; Schwörer, G; Schablowski, H; Psoma, A; Jakobs, KH (1999-10-15). "Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member". FEBS Letters . 459 (3): 313–318.
doi :
10.1016/s0014-5793(99)01270-3 .
PMID
10526156 .
S2CID
8529412 .
^ Fukuhara S, Chikumi H, Gutkind JS (November 2000).
"Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho" . FEBS Letters . 485 (2–3): 183–8.
doi :
10.1016/S0014-5793(00)02224-9 .
PMID
11094164 .
S2CID
7300556 .
^
a
b Suzuki N, Nakamura S, Mano H, Kozasa T (January 2003).
"Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF" . Proceedings of the National Academy of Sciences of the United States of America . 100 (2): 733–8.
Bibcode :
2003PNAS..100..733S .
doi :
10.1073/pnas.0234057100 .
PMC
141065 .
PMID
12515866 .
^ Dhanasekaran N, Dermott JM (1996). "Signaling by the G12 class of G proteins". Cell. Signal . 8 (4): 235–45.
doi :
10.1016/0898-6568(96)00048-4 .
PMID
8842523 .
^ Yamaguchi Y, Katoh H, Mori K, Negishi M (August 2002).
"Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity" . Current Biology . 12 (15): 1353–8.
doi :
10.1016/S0960-9822(02)01034-5 .
PMID
12176367 .
S2CID
11485795 .
^ Vaiskunaite R, Kozasa T, Voyno-Yasenetskaya TA (December 2001).
"Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling" . The Journal of Biological Chemistry . 276 (49): 46088–93.
doi :
10.1074/jbc.M108711200 .
PMID
11598136 .
^ Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY (September 2011).
"Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization" . The Journal of Biological Chemistry . 286 (35): 31055–61.
doi :
10.1074/jbc.M111.253427 .
PMC
3162464 .
PMID
21771786 .
External links