Dual specificity tyrosine-phosphorylation-regulated kinase 3 is an
enzyme that in humans is encoded by the DYRK3gene.[5][6]
This gene product belongs to the DYRK family of
dual-specificity protein kinases that catalyze
autophosphorylation on
serine/
threonine and
tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to
autophosphorylate on tyrosine residue and catalyze phosphorylation of
histonesH3 and
H2B in vitro.
Alternatively spliced transcript variants encoding different isoforms have been identified.[6]
Zhang D, Li K, Erickson-Miller CL, et al. (2005). "DYRK gene structure and erythroid-restricted features of DYRK3 gene expression". Genomics. 85 (1): 117–30.
doi:
10.1016/j.ygeno.2004.08.021.
PMID15607427.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101.
doi:
10.1038/nbt1046.
PMID15592455.
S2CID7200157.
Xia J, Yang X, Ruan Q, et al. (1999). "[Molecular cloning and characterization of novel protein kinase gene DYRK3]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 15 (6): 327–32.
PMID9845759.
Dual specificity tyrosine-phosphorylation-regulated kinase 3 is an
enzyme that in humans is encoded by the DYRK3gene.[5][6]
This gene product belongs to the DYRK family of
dual-specificity protein kinases that catalyze
autophosphorylation on
serine/
threonine and
tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to
autophosphorylate on tyrosine residue and catalyze phosphorylation of
histonesH3 and
H2B in vitro.
Alternatively spliced transcript variants encoding different isoforms have been identified.[6]
Zhang D, Li K, Erickson-Miller CL, et al. (2005). "DYRK gene structure and erythroid-restricted features of DYRK3 gene expression". Genomics. 85 (1): 117–30.
doi:
10.1016/j.ygeno.2004.08.021.
PMID15607427.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101.
doi:
10.1038/nbt1046.
PMID15592455.
S2CID7200157.
Xia J, Yang X, Ruan Q, et al. (1999). "[Molecular cloning and characterization of novel protein kinase gene DYRK3]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 15 (6): 327–32.
PMID9845759.