Interferon-induced GTP-binding protein Mx1 is a
protein that in humans is encoded by the
MX1 gene.[5][6]
In
mice, the
interferon-inducible Mx protein is responsible for a specific antiviral state against
influenza virusinfection. Furthermore, the human orthologue MxA is a major determinant for influenza viruses of animal origin.[7] The protein encoded by this
gene is similar to the mouse protein as determined by its
antigenic relatedness, induction conditions, physicochemical properties, and
amino acid analysis. This
cytoplasmic protein is a member of both the
dynamin superfamily and the family of large
GTPases.[6]
Weitz G, Bekisz J, Zoon K, Arnheiter H (1990). "Purification and characterization of a human Mx protein". J. Interferon Res. 9 (6): 679–89.
doi:
10.1089/jir.1989.9.679.
PMID2607176.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Hijikata M, Ohta Y, Mishiro S (2000). "Identification of a single nucleotide polymorphism in the MxA gene promoter (G/T at nt -88) correlated with the response of hepatitis C patients to interferon". Intervirology. 43 (2): 124–7.
doi:
10.1159/000025035.
PMID10971132.
S2CID19445539.
Engelhardt OG, Ullrich E, Kochs G, Haller O (2002). "Interferon-induced antiviral Mx1 GTPase is associated with components of the SUMO-1 system and promyelocytic leukemia protein nuclear bodies". Exp. Cell Res. 271 (2): 286–95.
doi:
10.1006/excr.2001.5380.
PMID11716541.
Hijikata M, Mishiro S, Miyamoto C, et al. (2002). "Genetic polymorphism of the MxA gene promoter and interferon responsiveness of hepatitis C patients: revisited by analyzing two SNP sites (-123 and -88) in vivo and in vitro". Intervirology. 44 (6): 379–82.
doi:
10.1159/000050075.
PMID11805446.
S2CID46752867.
Interferon-induced GTP-binding protein Mx1 is a
protein that in humans is encoded by the
MX1 gene.[5][6]
In
mice, the
interferon-inducible Mx protein is responsible for a specific antiviral state against
influenza virusinfection. Furthermore, the human orthologue MxA is a major determinant for influenza viruses of animal origin.[7] The protein encoded by this
gene is similar to the mouse protein as determined by its
antigenic relatedness, induction conditions, physicochemical properties, and
amino acid analysis. This
cytoplasmic protein is a member of both the
dynamin superfamily and the family of large
GTPases.[6]
Weitz G, Bekisz J, Zoon K, Arnheiter H (1990). "Purification and characterization of a human Mx protein". J. Interferon Res. 9 (6): 679–89.
doi:
10.1089/jir.1989.9.679.
PMID2607176.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Hijikata M, Ohta Y, Mishiro S (2000). "Identification of a single nucleotide polymorphism in the MxA gene promoter (G/T at nt -88) correlated with the response of hepatitis C patients to interferon". Intervirology. 43 (2): 124–7.
doi:
10.1159/000025035.
PMID10971132.
S2CID19445539.
Engelhardt OG, Ullrich E, Kochs G, Haller O (2002). "Interferon-induced antiviral Mx1 GTPase is associated with components of the SUMO-1 system and promyelocytic leukemia protein nuclear bodies". Exp. Cell Res. 271 (2): 286–95.
doi:
10.1006/excr.2001.5380.
PMID11716541.
Hijikata M, Mishiro S, Miyamoto C, et al. (2002). "Genetic polymorphism of the MxA gene promoter and interferon responsiveness of hepatitis C patients: revisited by analyzing two SNP sites (-123 and -88) in vivo and in vitro". Intervirology. 44 (6): 379–82.
doi:
10.1159/000050075.
PMID11805446.
S2CID46752867.