Interferon-induced GTP-binding protein Mx2 is a
protein that in humans is encoded by the MX2gene.[3][4][5]
The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the
dynamin family and the family of large
GTPases. The nuclear form is localized in a granular pattern in the
heterochromatin region beneath the
nuclear envelope. A
nuclear localization signal (NLS) is present at the
amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon.
Antiviral activity
This protein is upregulated by
interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1.[5]
MX2/MXB has antiviral activity against
HIV-1.[6][7][8][9][10][11][12] MXB is also a restriction factor for
herpesviruses, which acts at a very early stage of the replication cycle and MX2/MXB restriction of herpesvirus requires GTPase activity.[13][14][15][16]
Horisberger MA, Wathelet M, Szpirer J, Szpirer C, Islam Q, Levan G, et al. (March 1988). "cDNA cloning and assignment to chromosome 21 of IFI-78K gene, the human equivalent of murine Mx gene". Somatic Cell and Molecular Genetics. 14 (2): 123–31.
doi:
10.1007/BF01534397.
PMID3162334.
S2CID31805827.
Interferon-induced GTP-binding protein Mx2 is a
protein that in humans is encoded by the MX2gene.[3][4][5]
The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the
dynamin family and the family of large
GTPases. The nuclear form is localized in a granular pattern in the
heterochromatin region beneath the
nuclear envelope. A
nuclear localization signal (NLS) is present at the
amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon.
Antiviral activity
This protein is upregulated by
interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1.[5]
MX2/MXB has antiviral activity against
HIV-1.[6][7][8][9][10][11][12] MXB is also a restriction factor for
herpesviruses, which acts at a very early stage of the replication cycle and MX2/MXB restriction of herpesvirus requires GTPase activity.[13][14][15][16]
Horisberger MA, Wathelet M, Szpirer J, Szpirer C, Islam Q, Levan G, et al. (March 1988). "cDNA cloning and assignment to chromosome 21 of IFI-78K gene, the human equivalent of murine Mx gene". Somatic Cell and Molecular Genetics. 14 (2): 123–31.
doi:
10.1007/BF01534397.
PMID3162334.
S2CID31805827.