This gene encodes a member of the human ARF gene family, which is part of the
Ras superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A
pseudogene of this gene is located on chromosome 7.[5]
Sabe H (2004). "Requirement for Arf6 in cell adhesion, migration, and cancer cell invasion". J. Biochem. 134 (4): 485–9.
doi:
10.1093/jb/mvg181.
PMID14607973.
Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection". Curr. HIV Res. 3 (1): 87–94.
doi:
10.2174/1570162052773013.
PMID15638726.
D'Souza-Schorey C, Stahl PD (1995). "Myristoylation is required for the intracellular localization and endocytic function of ARF6". Exp. Cell Res. 221 (1): 153–9.
doi:
10.1006/excr.1995.1362.
PMID7589240.
Radhakrishna H, Al-Awar O, Khachikian Z, Donaldson JG (1999). "ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements". J. Cell Sci. 112 (6): 855–66.
doi:
10.1242/jcs.112.6.855.
PMID10036235.
Kim HS (1999). "Assignment of the human ADP-ribosylation factor 6 (ARF6) gene to chromosome 7q22.1 by radiation hybrid mapping". Cytogenet. Cell Genet. 84 (1–2): 94.
doi:
10.1159/000015225.
PMID10343114.
S2CID31452287.
This gene encodes a member of the human ARF gene family, which is part of the
Ras superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A
pseudogene of this gene is located on chromosome 7.[5]
Sabe H (2004). "Requirement for Arf6 in cell adhesion, migration, and cancer cell invasion". J. Biochem. 134 (4): 485–9.
doi:
10.1093/jb/mvg181.
PMID14607973.
Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection". Curr. HIV Res. 3 (1): 87–94.
doi:
10.2174/1570162052773013.
PMID15638726.
D'Souza-Schorey C, Stahl PD (1995). "Myristoylation is required for the intracellular localization and endocytic function of ARF6". Exp. Cell Res. 221 (1): 153–9.
doi:
10.1006/excr.1995.1362.
PMID7589240.
Radhakrishna H, Al-Awar O, Khachikian Z, Donaldson JG (1999). "ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements". J. Cell Sci. 112 (6): 855–66.
doi:
10.1242/jcs.112.6.855.
PMID10036235.
Kim HS (1999). "Assignment of the human ADP-ribosylation factor 6 (ARF6) gene to chromosome 7q22.1 by radiation hybrid mapping". Cytogenet. Cell Genet. 84 (1–2): 94.
doi:
10.1159/000015225.
PMID10343114.
S2CID31452287.