Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 is an
enzyme that in
humans is encoded by the ATP2A3gene.[5][6]
This gene encodes one of the SERCA Ca2+-ATPases, which are intracellular pumps located in the
sarcoplasmic or
endoplasmic reticula of cells. SERCA3 expression was originally described as non-muscular, but was recently observed in
cardiomyocyte. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of
calcium from the
cytosol to the sarcoplasmic reticulum
lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in 6 transcript variants encoding different isoforms named SERCA3a to SERCA3f.[6]
Cancer
ATP2A3 gene has been observed progressively downregulated in
Human papillomavirus-positive
neoplastic keratinocytes derived from uterine cervical
preneoplastic lesions at different levels of malignancy.[7] For this reason, ATP2A3 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical
preneoplastic lesions progression.[7]
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9.
doi:
10.1038/nbt810.
PMID12665801.
S2CID23783563.
Chaâbane C, Corvazier E, Bredoux R, et al. (2006). "Sarco/endoplasmic reticulum Ca2+ATPase type 3 isoforms (SERCA3b and SERCA3f): distinct roles in cell adhesion and ER stress". Biochem. Biophys. Res. Commun. 345 (4): 1377–85.
doi:
10.1016/j.bbrc.2006.05.054.
PMID16725111.
Bredoux R, Corvazier E, Dally S, et al. (2006). "Human platelet Ca2+-ATPases: new markers of cell differentiation as illustrated in idiopathic scoliosis". Platelets. 17 (6): 421–33.
doi:
10.1080/09537100600758719.
PMID16973504.
S2CID24473757.
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 is an
enzyme that in
humans is encoded by the ATP2A3gene.[5][6]
This gene encodes one of the SERCA Ca2+-ATPases, which are intracellular pumps located in the
sarcoplasmic or
endoplasmic reticula of cells. SERCA3 expression was originally described as non-muscular, but was recently observed in
cardiomyocyte. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of
calcium from the
cytosol to the sarcoplasmic reticulum
lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in 6 transcript variants encoding different isoforms named SERCA3a to SERCA3f.[6]
Cancer
ATP2A3 gene has been observed progressively downregulated in
Human papillomavirus-positive
neoplastic keratinocytes derived from uterine cervical
preneoplastic lesions at different levels of malignancy.[7] For this reason, ATP2A3 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical
preneoplastic lesions progression.[7]
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9.
doi:
10.1038/nbt810.
PMID12665801.
S2CID23783563.
Chaâbane C, Corvazier E, Bredoux R, et al. (2006). "Sarco/endoplasmic reticulum Ca2+ATPase type 3 isoforms (SERCA3b and SERCA3f): distinct roles in cell adhesion and ER stress". Biochem. Biophys. Res. Commun. 345 (4): 1377–85.
doi:
10.1016/j.bbrc.2006.05.054.
PMID16725111.
Bredoux R, Corvazier E, Dally S, et al. (2006). "Human platelet Ca2+-ATPases: new markers of cell differentiation as illustrated in idiopathic scoliosis". Platelets. 17 (6): 421–33.
doi:
10.1080/09537100600758719.
PMID16973504.
S2CID24473757.