Potassium-transporting ATPase alpha chain 2 is a
protein that in humans is encoded by the ATP12Agene.[5][6][7][8]
Function
The protein encoded by this gene belongs to the family of
P-type cation transport
ATPases. This gene encodes a catalytic subunit of the
ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. It is also responsible for potassium absorption in various tissues.[6]
^Sverdlov VE, Kostina MB, Modyanov NN (March 1996). "Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase". Genomics. 32 (3): 317–27.
doi:
10.1006/geno.1996.0125.
PMID8838794.
^Yang-Feng TL, Schneider JW, Lindgren V, Shull MM, Benz EJ, Lingrel JB, Francke U (February 1988). "Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes". Genomics. 2 (2): 128–38.
doi:
10.1016/0888-7543(88)90094-8.
PMID2842249.
Sverdlov VE, Kostina MB, Modyanov NN (1997). "Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase". Genomics. 32 (3): 317–27.
doi:
10.1006/geno.1996.0125.
PMID8838794.
Pestov NB, Korneenko TV, Adams G, et al. (2002). "Nongastric H-K-ATPase in rodent prostate: lobe-specific expression and apical localization". Am. J. Physiol., Cell Physiol. 282 (4): C907–16.
doi:
10.1152/ajpcell.00258.2001.
PMID11880279.
S2CID19898937.
Reinhardt J, Kosch M, Lerner M, et al. (2002). "Stimulation of protein kinase C pathway mediates endocytosis of human nongastric H+-K+-ATPase, ATP1AL1". Am. J. Physiol. Renal Physiol. 283 (2): F335–43.
doi:
10.1152/ajprenal.00226.2001.
PMID12110518.
S2CID7158036.
Johansson M, Jansson T, Pestov NB, Powell TL (2004). "Non-gastric H+/K+ ATPase is present in the microvillous membrane of the human placental syncytiotrophoblast". Placenta. 25 (6): 505–11.
doi:
10.1016/j.placenta.2003.11.008.
PMID15135233.
Potassium-transporting ATPase alpha chain 2 is a
protein that in humans is encoded by the ATP12Agene.[5][6][7][8]
Function
The protein encoded by this gene belongs to the family of
P-type cation transport
ATPases. This gene encodes a catalytic subunit of the
ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. It is also responsible for potassium absorption in various tissues.[6]
^Sverdlov VE, Kostina MB, Modyanov NN (March 1996). "Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase". Genomics. 32 (3): 317–27.
doi:
10.1006/geno.1996.0125.
PMID8838794.
^Yang-Feng TL, Schneider JW, Lindgren V, Shull MM, Benz EJ, Lingrel JB, Francke U (February 1988). "Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes". Genomics. 2 (2): 128–38.
doi:
10.1016/0888-7543(88)90094-8.
PMID2842249.
Sverdlov VE, Kostina MB, Modyanov NN (1997). "Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase". Genomics. 32 (3): 317–27.
doi:
10.1006/geno.1996.0125.
PMID8838794.
Pestov NB, Korneenko TV, Adams G, et al. (2002). "Nongastric H-K-ATPase in rodent prostate: lobe-specific expression and apical localization". Am. J. Physiol., Cell Physiol. 282 (4): C907–16.
doi:
10.1152/ajpcell.00258.2001.
PMID11880279.
S2CID19898937.
Reinhardt J, Kosch M, Lerner M, et al. (2002). "Stimulation of protein kinase C pathway mediates endocytosis of human nongastric H+-K+-ATPase, ATP1AL1". Am. J. Physiol. Renal Physiol. 283 (2): F335–43.
doi:
10.1152/ajprenal.00226.2001.
PMID12110518.
S2CID7158036.
Johansson M, Jansson T, Pestov NB, Powell TL (2004). "Non-gastric H+/K+ ATPase is present in the microvillous membrane of the human placental syncytiotrophoblast". Placenta. 25 (6): 505–11.
doi:
10.1016/j.placenta.2003.11.008.
PMID15135233.