V-type proton ATPase subunit e 1 is an
enzyme that in humans is encoded by the ATP6V0E1gene.[5][6][7]
This gene encodes a component of
vacuolarATPase (
V-ATPase), a
multisubunit enzyme that mediates acidification of
eukaryoticintracellularorganelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as
protein sorting,
zymogen activation,
receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a
cytosolic V1 domain and a
transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP
catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional
isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is possibly part of the V0 subunit. Since two nontranscribed
pseudogenes have been found in dogs, it is possible that the localization to
chromosome 2 for this gene by
radiation hybrid mapping is representing a pseudogene.
Genomic mapping puts the chromosomal location on 5q35.3.[7]
Stevens TH, Forgac M (1998). "Structure, function and regulation of the vacuolar (H+)-ATPase". Annual Review of Cell and Developmental Biology. 13: 779–808.
doi:
10.1146/annurev.cellbio.13.1.779.
PMID9442887.
V-type proton ATPase subunit e 1 is an
enzyme that in humans is encoded by the ATP6V0E1gene.[5][6][7]
This gene encodes a component of
vacuolarATPase (
V-ATPase), a
multisubunit enzyme that mediates acidification of
eukaryoticintracellularorganelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as
protein sorting,
zymogen activation,
receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a
cytosolic V1 domain and a
transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP
catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional
isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is possibly part of the V0 subunit. Since two nontranscribed
pseudogenes have been found in dogs, it is possible that the localization to
chromosome 2 for this gene by
radiation hybrid mapping is representing a pseudogene.
Genomic mapping puts the chromosomal location on 5q35.3.[7]
Stevens TH, Forgac M (1998). "Structure, function and regulation of the vacuolar (H+)-ATPase". Annual Review of Cell and Developmental Biology. 13: 779–808.
doi:
10.1146/annurev.cellbio.13.1.779.
PMID9442887.