Guanine nucleotide-binding protein subunit beta-5 is a
protein that in humans is encoded by the GNB5gene.[5] Alternatively spliced transcript variants encoding different isoforms exist.[6]
Function
Heterotrimeric guanine nucleotide-binding proteins (
G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.[6]
GNB5 has been shown to differentially control
RGS protein stability and membrane anchor binding, and therefore is involved in the control of complex neuronal G protein signaling pathways.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Jones PG, Lombardi SJ, Cockett MI (Jun 1998). "Cloning and tissue distribution of the human G protein beta 5 cDNA". Biochim. Biophys. Acta. 1402 (3): 288–91.
doi:
10.1016/S0167-4889(98)00017-2.
PMID9606987.
Ajit SK, Young KH (2004). "Enhancement of pheromone response by RGS9 and Gbeta5 in yeast". Biochem. Biophys. Res. Commun. 324 (2): 686–91.
doi:
10.1016/j.bbrc.2004.09.100.
PMID15474482.
Guanine nucleotide-binding protein subunit beta-5 is a
protein that in humans is encoded by the GNB5gene.[5] Alternatively spliced transcript variants encoding different isoforms exist.[6]
Function
Heterotrimeric guanine nucleotide-binding proteins (
G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.[6]
GNB5 has been shown to differentially control
RGS protein stability and membrane anchor binding, and therefore is involved in the control of complex neuronal G protein signaling pathways.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Jones PG, Lombardi SJ, Cockett MI (Jun 1998). "Cloning and tissue distribution of the human G protein beta 5 cDNA". Biochim. Biophys. Acta. 1402 (3): 288–91.
doi:
10.1016/S0167-4889(98)00017-2.
PMID9606987.
Ajit SK, Young KH (2004). "Enhancement of pheromone response by RGS9 and Gbeta5 in yeast". Biochem. Biophys. Res. Commun. 324 (2): 686–91.
doi:
10.1016/j.bbrc.2004.09.100.
PMID15474482.