Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 is a
protein that in humans is encoded by the GNB1gene.[5]
Function
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals.[5][6]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
Mutations in the GNB1 gene can cause developmental delays, seizures, and other health problems. The GNB1 Advocacy Group is the primary organization in the United States connecting patients to each other and to researchers working to cure the effects of these mutations.
Codina J, Stengel D, Woo SL, Birnbaumer L (1986). "Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical". FEBS Lett. 207 (2): 187–92.
doi:
10.1016/0014-5793(86)81486-7.
PMID3095147.
S2CID22783787.
Huang CL, Jan YN, Jan LY (1997). "Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels". FEBS Lett. 405 (3): 291–8.
doi:
10.1016/S0014-5793(97)00197-X.
PMID9108307.
S2CID44072628.
Overview of all the structural information available in the
PDB for
UniProt: P62873 (Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1) at the
PDBe-KB.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 is a
protein that in humans is encoded by the GNB1gene.[5]
Function
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals.[5][6]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
Mutations in the GNB1 gene can cause developmental delays, seizures, and other health problems. The GNB1 Advocacy Group is the primary organization in the United States connecting patients to each other and to researchers working to cure the effects of these mutations.
Codina J, Stengel D, Woo SL, Birnbaumer L (1986). "Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical". FEBS Lett. 207 (2): 187–92.
doi:
10.1016/0014-5793(86)81486-7.
PMID3095147.
S2CID22783787.
Huang CL, Jan YN, Jan LY (1997). "Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels". FEBS Lett. 405 (3): 291–8.
doi:
10.1016/S0014-5793(97)00197-X.
PMID9108307.
S2CID44072628.
Overview of all the structural information available in the
PDB for
UniProt: P62873 (Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1) at the
PDBe-KB.