Monoamine-depleting agents are a group of drugs which reversibly deplete one or more monoamine neurotransmitters. [1] [2] One mechanism by which these agents act is by inhibiting reuptake by the vesicular monoamine transporters, VMAT1 and VMAT2. [2] [3] Examples of monoamine-depleting agents include deutetrabenazine, oxypertine, reserpine, tetrabenazine, and valbenazine. [1] [2] [3]
References
- ^ a b Carlsson A (1975). "Monoamine-depleting drugs". Pharmacol Ther B. 1 (3): 393–400. doi: 10.1016/0306-039x(75)90045-8. PMID 772709.
- ^ a b c Vijayakumar D, Jankovic J (May 2016). "Drug-Induced Dyskinesia, Part 2: Treatment of Tardive Dyskinesia". Drugs. 76 (7): 779–87. doi: 10.1007/s40265-016-0568-1. PMID 27091214. S2CID 13570794.
- ^ a b Guay DR (August 2010). "Tetrabenazine, a monoamine-depleting drug used in the treatment of hyperkinetic movement disorders". Am J Geriatr Pharmacother. 8 (4): 331–73. doi: 10.1016/j.amjopharm.2010.08.006. PMID 20869622.
Monoamine-depleting agents are a group of drugs which reversibly deplete one or more monoamine neurotransmitters. [1] [2] One mechanism by which these agents act is by inhibiting reuptake by the vesicular monoamine transporters, VMAT1 and VMAT2. [2] [3] Examples of monoamine-depleting agents include deutetrabenazine, oxypertine, reserpine, tetrabenazine, and valbenazine. [1] [2] [3]
References
- ^ a b Carlsson A (1975). "Monoamine-depleting drugs". Pharmacol Ther B. 1 (3): 393–400. doi: 10.1016/0306-039x(75)90045-8. PMID 772709.
- ^ a b c Vijayakumar D, Jankovic J (May 2016). "Drug-Induced Dyskinesia, Part 2: Treatment of Tardive Dyskinesia". Drugs. 76 (7): 779–87. doi: 10.1007/s40265-016-0568-1. PMID 27091214. S2CID 13570794.
- ^ a b Guay DR (August 2010). "Tetrabenazine, a monoamine-depleting drug used in the treatment of hyperkinetic movement disorders". Am J Geriatr Pharmacother. 8 (4): 331–73. doi: 10.1016/j.amjopharm.2010.08.006. PMID 20869622.