Mitogen-activated protein kinase 1 (MAPK 1), also known as ERK2, is an
enzyme that in humans is encoded by the MAPK1gene.[5]
Function
The protein encoded by this gene is a member of the
MAP kinase family. MAP kinases, also known as
extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as
proliferation,
differentiation, transcription regulation and development. The activation of this
kinase requires its
phosphorylation by upstream
kinases. Upon activation, this kinase translocates to the
nucleus of the stimulated cells, where it
phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the
UTRs, have been reported for this gene.[6] MAPK1 contains multiple amino acid sites that are phosphorylated and ubiquitinated.[7]
^Cano E, Hazzalin CA, Kardalinou E, Buckle RS, Mahadevan LC (November 1995). "Neither ERK nor JNK/SAPK MAP kinase subtypes are essential for histone H3/HMG-14 phosphorylation or c-fos and c-jun induction". J. Cell Sci. 108 (11): 3599–609.
doi:
10.1242/jcs.108.11.3599.
PMID8586671.
^Lou Y, Xie W, Zhang DF, Yao JH, Luo ZF, Wang YZ, Shi YY, Yao XB (August 2004). "Nek2A specifies the centrosomal localization of Erk2". Biochem. Biophys. Res. Commun. 321 (2): 495–501.
doi:
10.1016/j.bbrc.2004.06.171.
PMID15358203.
^Pettiford SM, Herbst R (February 2000). "The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP". Oncogene. 19 (7): 858–69.
doi:
10.1038/sj.onc.1203408.
PMID10702794.
S2CID24843974.
Morishima-Kawashima M, Hasegawa M, Takio K, Suzuki M, Yoshida H, Watanabe A, Titani K, Ihara Y (1995). "Hyperphosphorylation of tau in PHF". Neurobiol. Aging. 16 (3): 365–71, discussion 371–80.
doi:
10.1016/0197-4580(95)00027-C.
PMID7566346.
S2CID22471158.
Jeong Y, Du R, Zhu X, et al. (2014). "Histone deacetylase isoforms regulate innate immune responses by deacetylating mitogen-activated protein kinase phosphatase-1". J Leukoc Biol. 95 (4): 651–9.
doi:
10.1189/jlb.1013565.
PMID24374966.
S2CID40126163.
Peruzzi F, Gordon J, Darbinian N, Amini S (2002). "Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway". J. Neurovirol. 8 Suppl 2 (2): 91–6.
doi:
10.1080/13550280290167885.
PMID12491158.
Greenway AL, Holloway G, McPhee DA, Ellis P, Cornall A, Lidman M (2003). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication". J. Biosci. 28 (3): 323–35.
doi:
10.1007/BF02970151.
PMID12734410.
S2CID33749514.
Meloche S, Pouysségur J (2007). "The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition". Oncogene. 26 (22): 3227–39.
doi:
10.1038/sj.onc.1210414.
PMID17496918.
S2CID2245848.
1gol: COORDINATES OF RAT MAP KINASE ERK2 WITH AN ARGININE MUTATION AT POSITION 52
1pme: STRUCTURE OF PENTA MUTANT HUMAN ERK2 MAP KINASE COMPLEXED WITH A SPECIFIC INHIBITOR OF HUMAN P38 MAP KINASE
1tvo: The structure of ERK2 in complex with a small molecule inhibitor
1wzy: Crystal structure of human ERK2 complexed with a pyrazolopyridazine derivative
2erk: PHOSPHORYLATED MAP KINASE ERK2
2fys: Crystal structure of Erk2 complex with KIM peptide derived from MKP3
2gph: Docking motif interactions in the MAP kinase ERK2
2ojg: Crystal structure of ERK2 in complex with N,N-dimethyl-4-(4-phenyl-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide
2oji: Crystal structure of ERK2 in complex with N-benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide
2ojj: Crystal structure of ERK2 in complex with (S)-N-(1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide
3erk: THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/SB220025
4erk: THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/OLOMOUCINE
Mitogen-activated protein kinase 1 (MAPK 1), also known as ERK2, is an
enzyme that in humans is encoded by the MAPK1gene.[5]
Function
The protein encoded by this gene is a member of the
MAP kinase family. MAP kinases, also known as
extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as
proliferation,
differentiation, transcription regulation and development. The activation of this
kinase requires its
phosphorylation by upstream
kinases. Upon activation, this kinase translocates to the
nucleus of the stimulated cells, where it
phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the
UTRs, have been reported for this gene.[6] MAPK1 contains multiple amino acid sites that are phosphorylated and ubiquitinated.[7]
^Cano E, Hazzalin CA, Kardalinou E, Buckle RS, Mahadevan LC (November 1995). "Neither ERK nor JNK/SAPK MAP kinase subtypes are essential for histone H3/HMG-14 phosphorylation or c-fos and c-jun induction". J. Cell Sci. 108 (11): 3599–609.
doi:
10.1242/jcs.108.11.3599.
PMID8586671.
^Lou Y, Xie W, Zhang DF, Yao JH, Luo ZF, Wang YZ, Shi YY, Yao XB (August 2004). "Nek2A specifies the centrosomal localization of Erk2". Biochem. Biophys. Res. Commun. 321 (2): 495–501.
doi:
10.1016/j.bbrc.2004.06.171.
PMID15358203.
^Pettiford SM, Herbst R (February 2000). "The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP". Oncogene. 19 (7): 858–69.
doi:
10.1038/sj.onc.1203408.
PMID10702794.
S2CID24843974.
Morishima-Kawashima M, Hasegawa M, Takio K, Suzuki M, Yoshida H, Watanabe A, Titani K, Ihara Y (1995). "Hyperphosphorylation of tau in PHF". Neurobiol. Aging. 16 (3): 365–71, discussion 371–80.
doi:
10.1016/0197-4580(95)00027-C.
PMID7566346.
S2CID22471158.
Jeong Y, Du R, Zhu X, et al. (2014). "Histone deacetylase isoforms regulate innate immune responses by deacetylating mitogen-activated protein kinase phosphatase-1". J Leukoc Biol. 95 (4): 651–9.
doi:
10.1189/jlb.1013565.
PMID24374966.
S2CID40126163.
Peruzzi F, Gordon J, Darbinian N, Amini S (2002). "Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway". J. Neurovirol. 8 Suppl 2 (2): 91–6.
doi:
10.1080/13550280290167885.
PMID12491158.
Greenway AL, Holloway G, McPhee DA, Ellis P, Cornall A, Lidman M (2003). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication". J. Biosci. 28 (3): 323–35.
doi:
10.1007/BF02970151.
PMID12734410.
S2CID33749514.
Meloche S, Pouysségur J (2007). "The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition". Oncogene. 26 (22): 3227–39.
doi:
10.1038/sj.onc.1210414.
PMID17496918.
S2CID2245848.
1gol: COORDINATES OF RAT MAP KINASE ERK2 WITH AN ARGININE MUTATION AT POSITION 52
1pme: STRUCTURE OF PENTA MUTANT HUMAN ERK2 MAP KINASE COMPLEXED WITH A SPECIFIC INHIBITOR OF HUMAN P38 MAP KINASE
1tvo: The structure of ERK2 in complex with a small molecule inhibitor
1wzy: Crystal structure of human ERK2 complexed with a pyrazolopyridazine derivative
2erk: PHOSPHORYLATED MAP KINASE ERK2
2fys: Crystal structure of Erk2 complex with KIM peptide derived from MKP3
2gph: Docking motif interactions in the MAP kinase ERK2
2ojg: Crystal structure of ERK2 in complex with N,N-dimethyl-4-(4-phenyl-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide
2oji: Crystal structure of ERK2 in complex with N-benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide
2ojj: Crystal structure of ERK2 in complex with (S)-N-(1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide
3erk: THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/SB220025
4erk: THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/OLOMOUCINE