Proto-oncogene vav is a
protein that in humans is encoded by the VAV1gene.[5]
Function
The protein encoded by this
proto-oncogene is a member of the Dbl family of
guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in
hematopoiesis, playing a role in
T-cell and
B-cell development and activation. This particular GEF has been identified as the specific binding partner of
Nef proteins from
HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Han J, Luby-Phelps K, Das B, Shu X, Xia Y, Mosteller RD, Krishna UM,
Falck JR, White MA, Broek D (February 1998). "Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav". Science. 279 (5350): 558–60.
Bibcode:
1998Sci...279..558H.
doi:
10.1126/science.279.5350.558.
PMID9438848.
^Perez-Villar JJ, Whitney GS, Sitnick MT, Dunn RJ, Venkatesan S, O'Day K, Schieven GL, Lin TA, Kanner SB (August 2002). "Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav". Biochemistry. 41 (34): 10732–40.
doi:
10.1021/bi025554o.
PMID12186560.
^Lindholm CK, Henriksson ML, Hallberg B, Welsh M (July 2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells". Eur. J. Biochem. 269 (13): 3279–88.
doi:
10.1046/j.1432-1033.2002.03008.x.
PMID12084069.
Greenway AL, Holloway G, McPhee DA, Ellis P, Cornall A, Lidman M (2004). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication". J. Biosci. 28 (3): 323–35.
doi:
10.1007/BF02970151.
PMID12734410.
S2CID33749514.
Katzav S (2007). "Flesh and blood: the story of Vav1, a gene that signals in hematopoietic cells but can be transforming in human malignancies". Cancer Lett. 255 (2): 241–54.
doi:
10.1016/j.canlet.2007.04.015.
PMID17590270.
Adams JM, Houston H, Allen J, Lints T, Harvey R (1992). "The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization". Oncogene. 7 (4): 611–8.
PMID1565462.
Ramos-Morales F, Romero F, Schweighoffer F, Bismuth G, Camonis J, Tortolero M, Fischer S (1995). "The proline-rich region of Vav binds to Grb2 and Grb3-3". Oncogene. 11 (8): 1665–9.
PMID7478592.
Machide M, Mano H, Todokoro K (1995). "Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain". Oncogene. 11 (4): 619–25.
PMID7651724.
Proto-oncogene vav is a
protein that in humans is encoded by the VAV1gene.[5]
Function
The protein encoded by this
proto-oncogene is a member of the Dbl family of
guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in
hematopoiesis, playing a role in
T-cell and
B-cell development and activation. This particular GEF has been identified as the specific binding partner of
Nef proteins from
HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Han J, Luby-Phelps K, Das B, Shu X, Xia Y, Mosteller RD, Krishna UM,
Falck JR, White MA, Broek D (February 1998). "Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav". Science. 279 (5350): 558–60.
Bibcode:
1998Sci...279..558H.
doi:
10.1126/science.279.5350.558.
PMID9438848.
^Perez-Villar JJ, Whitney GS, Sitnick MT, Dunn RJ, Venkatesan S, O'Day K, Schieven GL, Lin TA, Kanner SB (August 2002). "Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav". Biochemistry. 41 (34): 10732–40.
doi:
10.1021/bi025554o.
PMID12186560.
^Lindholm CK, Henriksson ML, Hallberg B, Welsh M (July 2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells". Eur. J. Biochem. 269 (13): 3279–88.
doi:
10.1046/j.1432-1033.2002.03008.x.
PMID12084069.
Greenway AL, Holloway G, McPhee DA, Ellis P, Cornall A, Lidman M (2004). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication". J. Biosci. 28 (3): 323–35.
doi:
10.1007/BF02970151.
PMID12734410.
S2CID33749514.
Katzav S (2007). "Flesh and blood: the story of Vav1, a gene that signals in hematopoietic cells but can be transforming in human malignancies". Cancer Lett. 255 (2): 241–54.
doi:
10.1016/j.canlet.2007.04.015.
PMID17590270.
Adams JM, Houston H, Allen J, Lints T, Harvey R (1992). "The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization". Oncogene. 7 (4): 611–8.
PMID1565462.
Ramos-Morales F, Romero F, Schweighoffer F, Bismuth G, Camonis J, Tortolero M, Fischer S (1995). "The proline-rich region of Vav binds to Grb2 and Grb3-3". Oncogene. 11 (8): 1665–9.
PMID7478592.
Machide M, Mano H, Todokoro K (1995). "Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain". Oncogene. 11 (4): 619–25.
PMID7651724.