From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Vinexin is a
protein that in humans is encoded by the SORBS3
gene .
[5]
[6]
[7]
Interactions
SORBS3 has been shown to
interact with
DLG5
[8] and
MAPK1 .
[9]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000120896 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000022091 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Kioka N, Sakata S, Kawauchi T, Amachi T, Akiyama SK, Okazaki K, Yaen C, Yamada KM, Aota S (Mar 1999).
"Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization" . J Cell Biol . 144 (1): 59–69.
doi :
10.1083/jcb.144.1.59 .
PMC
2148117 .
PMID
9885244 .
^ Kioka N (Jan 2003). "[A novel adaptor protein family regulating cytoskeletal organization and signal transduction--Vinexin, CAP/ponsin, ArgBP2]". Seikagaku . 74 (11): 1356–60.
PMID
12510380 .
^
"Entrez Gene: SORBS3 sorbin and SH3 domain containing 3" .
^ Wakabayashi M, Ito Takuya, Mitsushima Masaru, Aizawa Sanae, Ueda Kazumitsu, Amachi Teruo, Kioka Noriyuki (Jun 2003).
"Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact" . J. Biol. Chem . 278 (24): 21709–14.
doi :
10.1074/jbc.M211004200 .
ISSN
0021-9258 .
PMID
12657639 .
^ Mitsushima M, Suwa Akira, Amachi Teruo, Ueda Kazumitsu, Kioka Noriyuki (Aug 2004).
"Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin" . J. Biol. Chem . 279 (33): 34570–7.
doi :
10.1074/jbc.M402304200 .
ISSN
0021-9258 .
PMID
15184391 .
Further reading
Akamatsu M, Aota S, Suwa A, et al. (2000).
"Vinexin forms a signaling complex with Sos and modulates epidermal growth factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activities" . J. Biol. Chem . 274 (50): 35933–7.
doi :
10.1074/jbc.274.50.35933 .
PMID
10585480 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Wakabayashi M, Ito T, Mitsushima M, et al. (2003).
"Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact" . J. Biol. Chem . 278 (24): 21709–14.
doi :
10.1074/jbc.M211004200 .
PMID
12657639 .
Townson SM, Dobrzycka KM, Lee AV, et al. (2003).
"SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor" . J. Biol. Chem . 278 (22): 20059–68.
doi :
10.1074/jbc.M212988200 .
PMID
12660241 .
Mitsushima M, Suwa A, Amachi T, et al. (2004).
"Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin" . J. Biol. Chem . 279 (33): 34570–7.
doi :
10.1074/jbc.M402304200 .
PMID
15184391 .
Martens N, Wery M, Wang P, et al. (2004). "The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin". Exp. Cell Res . 298 (1): 239–48.
doi :
10.1016/j.yexcr.2004.04.002 .
PMID
15242778 .
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004).
"Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5.
Bibcode :
2004PNAS..10112130B .
doi :
10.1073/pnas.0404720101 .
PMC
514446 .
PMID
15302935 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Bour G, Plassat JL, Bauer A, et al. (2005).
"Vinexin beta interacts with the non-phosphorylated AF-1 domain of retinoid receptor gamma (RARgamma) and represses RARgamma-mediated transcription" . J. Biol. Chem . 280 (17): 17027–37.
doi :
10.1074/jbc.M501344200 .
PMID
15734736 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8.
Bibcode :
2005Natur.437.1173R .
doi :
10.1038/nature04209 .
PMID
16189514 .
S2CID
4427026 .
Mitsushima M, Ueda K, Kioka N (2006).
"Vinexin beta regulates the phosphorylation of epidermal growth factor receptor on the cell surface" . Genes Cells . 11 (9): 971–82.
doi :
10.1111/j.1365-2443.2006.00995.x .
PMID
16923119 .
S2CID
24238810 .
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol . 24 (10): 1285–92.
doi :
10.1038/nbt1240 .
PMID
16964243 .
S2CID
14294292 .
Olsen JV, Blagoev B, Gnad F, et al. (2006).
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48.
doi :
10.1016/j.cell.2006.09.026 .
PMID
17081983 .
S2CID
7827573 .
Mizutani K, Ito H, Iwamoto I, et al. (2007). "Essential roles of ERK-mediated phosphorylation of vinexin in cell spreading, migration and anchorage-independent growth". Oncogene . 26 (50): 7122–31.
doi :
10.1038/sj.onc.1210512 .
hdl :
20.500.12099/23093 .
PMID
17486060 .
S2CID
9284621 .
External links
PDB gallery
2ct3 : Solution Structure of the SH3 domain of the Vinexin protein
2dlm : Solution structure of the first SH3 domain of human vinexin
2nwm : Solution structure of the first SH3 domain of human Vinexin and its interaction with the peptides from Vinculin